Allergist & Immunologist Questions Allergist-Immunologist

Will an amoxicillin allergic reaction go away on its own?

I had an allergic reaction to amoxicillin almost 4 weeks ago. My hands and feet continue to swell and I have joint pain every morning. The swelling and joint pain are not as bad as it was 4 weeks ago, but it’s persistent throughout the day. By evening the swelling has gone down a little so that I can remove my ring, but by morning it’s very hard to get my ring off. Will this go away on its own?

Female | 41 years old
Complaint duration: 4 weeks

5 Answers

yes but a short course of prednisone ( say 2 weeks) is likely to facilitate improvement and less pain and less swelling and better function
Hello!

Great question - this can sometimes last up to 6 months and occasionally requires low-dose prednisone or NSAIDs. Please visit with your PCP/urgent care or rheumatologist for better direction.
Thanks so much!

Best regards,

Dr. Brionez
This may or may not be an allergic reaction. Hand swelling is more common in more severe drug eruptions rather than the standard morbilliform drug eruption. Joint pain is also not common with standard drug eruptions - that typically comes with serum sickness like reactions. At any rate, #1 take that ring off if you can - you don't want to swell more and then cause constriction. See a doctor so they can evaluate you and determine what the cause of the swelling and joints pain might be. Typically, standard drug eruptions only last 2-4 weeks as far as rash and swelling (if that occurs).

Warm Regards,

JJC
I am sorry you are experiencing discomfort now. Yes, with time, the symptoms will subside. However, you should see an allergist to go over your reaction as that will impact what type of antibiotics you will need to avoid from here on. You will greatly benefit from seeing an allergist. 

Monika Korff, MD
Most drug eruptions resolve once the causative medication is stopped. Since you have persistent joint swelling and pain, a consultation with a local rheumatologist is highly recommended.

Stephen Schleicher, MD