Dr. Frederick S Southwick MD
Infectious Disease Specialist | Infectious Disease
1600 SW Archer Rd Gainesville FL, 32610About
Dr. Frederick Southwick is an infectious disease specialist practicing in Gainesville, FL. Dr. Southwick specializes in infections that are difficult to diagnose or unresponsive to treatments, such as HIV or airborne infections from a foreign country. Infectious disease specialists usually work with conditions that are not treatable by a primary physician but it is important to keep contact with the primary physician in order to receive information about the patients history and for deciding which diagnostic tests are appropriate.
Education and Training
Columbia University College of Physicians and Surgeons 1973
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM- Infectious Disease
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Actin-based motility of the intracellular pathogen Listeria monocytogenes: assessing the inhibitory specificity of ABM-1 peptide analogues.
- Energetics of nucleotide hydrolysis in polymer assembly/disassembly: the cases of actin and tubulin.
- Profilin promotes barbed-end actin filament assembly without lowering the critical concentration.
- Shigella actin-based motility in the presence of truncated vinculin.
- Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells.
- Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing.
- The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.
- Actin-based phagosome motility.
- A direct-transfer polymerization model explains how the multiple profilin-binding sites in the actoclampin motor promote rapid actin-based motility.
- Actin-based endosome and phagosome rocketing in macrophages: activation by the secretagogue antagonists lanthanum and zinc.
- Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.
- Depolymerization of actin filaments by profilin. Effects of profilin on capping protein function.
- Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.
- CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar Typhimurium infection.
- Host cell actin assembly is necessary and likely to provide the propulsive force
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