The Link Between Psoriasis and Malignant Lymphoma Risk

58,138 patients with psoriasis were chosen for the study, and their data was analyzed in comparison to 4,303,731 in a control group from the general population. The incidence rates and calculate hazard ratios were found by using this data via Cox regression analysis for Hodgkin lymphoma, non-Hodgkin lymphoma and cutaneous T-cell lymphoma. The incidence rates were found to be higher for those with psoriasis. Specifically, in Hodgkin lymphoma, incident rates for those with psoriasis were found to be 1.02, as compared to the general population's 0.45 (95% CI 0.70-1.47). In non-Hodgkin it was found to be 4.04, compared to the general population's 2.68 (95% CI 3.36-4.87). For cutaneous T-cell lymphoma, the incident rate was 0.44 compared to the general population's 0.10 (95% CI 0.25-0.77).

When it came to the adjusted hazard ratios, they were adjusted for age, gender, and person-time using a Cox proportional hazards model, and there was an evident indication that the connection with Hodgkin lymphoma was becoming even clearer (1.50, 95% CI 1.01-2.23), although the associations were not particularly significant with non-Hodgkin lymphoma (1.02, 95%, CI 0.84-1.24) or cutaneous T-cell lymphoma (1.66, 95% CI 0.88-3.13).