General Practitioner Questions Psychiatrist

Can lamotrigine help anxiety?

I have high anxiety and have just had lamotrigine added to my citalopram. Can lamotrigine help anxiety?

Female | 41 years old
Complaint duration: 6 months
Medications: Citalopram 40mg Lamotrigine 200mg
Conditions: Anxiety

3 Answers

Even though it is not indicated to treat anxiety particularly as a monotherapy, it has been used successfully as an adjunct to antidepressant/anxiolytics medications to get enhanced anxiolytic effect.

Not by expertise but take a look at this link..
https://www.drugs.com/comments/lamotrigine/for-anxiety.html#:~:text=User%20Reviews%20for%20Lamotrigine%20to%20treat%20Anxiety&text=Lamotrigine%20has%20an%20average%20rating,24%25%20reported%20a%20negative%20effect.
or
https://www.psycom.net/depression.central.lamotrigine.html
or
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694550/
Lamotrigine monotherapy does not show current evidence of efficacy for any specific anxiety disorder, however, lamotrigine works especially well for a hypomanic/anxious or depressed presentation. If patients are resistant to treatment and show mixed anxiety/depression symptoms, a combination of an SSRI and lamotrigine can be considered. In our experience, many
treatment-resistant patients will respond to combination therapies
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694550/>.

Jeffrey L. Rausch, MD