Gastroenterologist Questions

Can my medication be crushed and taken with water?

They are:

1. Esomeprazole magnesium trihydrate 20 mg tablets

2. Motilium - V (domperidone maleate 12.7 mg pills)

Please note that I am not providing all personal details because I have been seen by a specialist and they have fully addressed my condition. That is, I am not looking for a treatment. However, I am looking for a second opinion regarding this specific question. If there are any details needed to answer this specific question, kindly let me know. Also, I'd appreciate if the answer to my query was justified with sources or medical explanation!

Thanks!

Male | 30 years old

2 Answers

Gastroenterologist
No , it can not be crushed ; as the pill is enteric coated to avoid inactivation of drug from stomach acid . If you crush it ; will lose protective coating and drug may not be that effective .
For esomeprazole, yes, the capsule can be opened and the granules are taken in water. For domperidone, instructions from the UK indicate that the tablets should be taken whole and not be crushed or chewed: https://www.medicines.org.uk/emc/files/pil.556.pdf