Rheumatologist Questions Rhematologist

I might have ALS?

I’ve had muscle twitching, cramping, and pain in my legs along with odd sensations and an uncomfortable feeling when I speak, I'm very scared it’s ALS, please help.

Male | 16 years old
Complaint duration: 2 months

3 Answers

I think seeing Neurologist is best recommendation
To begin with, ALS is not common in teenagers. The first symptom is usually fasciculations, which are tiny, barely perceptible flickerings of muscles. Leg pain, abnormalities in sensation, and "uncomfortable feelings" when speaking are not common symptoms of ALS. I suggest that you have your personal physician carry out an evaluation and possibly refer you to a neurologist for their opinion.
Thanks for your question.

ALS, or amyotrophic lateral sclerosis, is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Amyotrophic refers to muscle wasting. When a muscle has no nourishment, it "atrophies" or wastes away. "Lateral" identifies the areas in a person's spinal cord where portions of the nerve cells that signal and control the
muscles are located. As this area degenerates, it leads to scarring or hardening ("sclerosis") in the region.

Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their demise. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, people may lose the ability to speak, eat, move and breathe. The motor nerves that are affected when you have ALS are the motor neurons that provide voluntary movements and muscle control. Examples of voluntary movements are making the effort to reach for a smart phone or step off a curb. These actions are controlled by the muscles in the arms and legs.

There are two different types of ALS, sporadic and familial. Sporadic, which is the most common form of the disease in the U.S., accounts for 90 to 95 percent of all cases. It may affect anyone, anywhere. Familial ALS (FALS) accounts for 5 to 10 percent of all cases in the U.S. Familial ALS means the disease is inherited. In those families, there is a 50% chance each offspring will inherit the gene mutation and may develop the disease. French neurologist Jean-Martin Charcot discovered the disease in 1869.

Recent years have brought a wealth of new scientific understanding regarding the physiology of this disease. There are currently four drugs approved by the U.S. FDA to treat ALS (Riluzole, Nuedexta, Radicava, and Tiglutik).