“How does tablet Ondero help to control my diabetes?”

This drug is a member of the DPP4 class of drugs. It keeps your body from breaking down a hormone called GLP1. This hormone increases insulin when you eat and turns off glucagon when you are eating. It does not usually cause hypoglycemia if you are only taking it and not with a sulfonylurea drug or insulin. If your HgbA1C is 8%, the drug should lower it to less than 7.5%.

TJ

Ondero blocks the degration of a hormone in our body, Glp-1. Glp1 is made in the intestines and when one eats, it is released, then it goes to the pancreas, and then it causes release of insulin only if the glucose is elevated. I find ondero week and prefer the injectable weekly Glp-1 medications such as trulicity, ozempic, bydureon. There however is some nausea sometimes with the injectable but they work much better. I actually never us ondero because it is expensive and less effective. The side effect profile is very good though.

Ondero is the trade name of a drug in the class we call DPP-4 inhibitors. What this group of drugs does is to prevent breakdown of a hormone that is an important hormone in our metabolism. This hormone is produced by the gut and rises when we eat. It is called a GLP-T R.A. What this hormone does is stimulate insulin production, suppress glucagon (a hormone that raises blood sugar), slows stomach emptying so you are satisfied with less food & do not get hungry between meals and it effects the brain so you feel sated & less hungry. The problem is that a chemical in the blood will break this hormone down in about 3 minutes so it doesn't last long enough to do its job. What Ondero & several other drugs in this class do is block the enzyme that breaks down GLP-1 so it lasts a lot longer to do its job. You can take a GLP-1 also but it needs to be given by injection whereas Ondero & its cousins can be taken by mouth. That's great but the problem is that this class of drugs are not all that good. They will drop the HbA1c by about 0.5% while other drugs for diabetes will drop the A1c by 1-2%. So, you should be taking another drug like metformin, a GLP-1, insulin or a SGLT-2 drug to help it.

Good luck.