“In spite of antibiotics, my throat pain is persisting. What should I do?”

This is difficult to answer without further information. However, your situation may require a different antibiotic. Or, there is a possibility that the pain that you're experiencing in her throat is not due to a bacterial infection and antibiotics would not work in that situation. I would recommend consultation with an ear nose and throat physician to better ascertain the etiology of her problem so that a tailored treatment can be initiated.

If the pain is severe and persistent, an exam by your PCP or possibly an ENT specialist is needed. Make an appointment.  

Sometimes infection in the tonsil area persists despite antibiotics. An ENT surgeon can review this and decide if the tonsils may be better off coming out, or just shaved down with Coblation technology. The latter is about as effective but far less sore to recover from. Sometimes persisting throat pain is from non-infection such as laryngopharyngeal reflux of muscular pain around the voice box. Again, an ENT surgeon should review this to get the right diagnosis rather than giving more antibiotics.

Most sore throats are viral in origin, Abx will not be useful. Could be reflux, allergy, irritant exposure, etc. See ENT if persists for more than three weeks.