Dr. William C. Cole II, MD

Expert Publications

• Endothelium-derived hyperpolarizing factor(s): species and tissue heterogeneity.
• Activation of vascular smooth muscle K+ channels by endothelium-derived relaxing factors.
• Identification, cloning and expression of rabbit vascular smooth muscle Kv1.5 and comparison with native delayed rectifier K+ current.
• High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy.
• Cyclosporin A regulates the levels of cyclophilin A in neuroblastoma cells in culture.
• Adenosine 3',5'-cyclic monophosphate increases processing of amyloid precursor protein (APP) to beta-amyloid in neuroblastoma cells without changing APP levels or expression of APP mRNA.
• Multiple antioxidants in the prevention and treatment of Parkinson's disease.
• Multiple antioxidants in the prevention and treatment of neurodegenerative disease: analysis of biologic rationale.
• Multiple antioxidants in the prevention and treatment of Alzheimer disease: analysis of biologic rationale.
• Vitamin E (d-alpha-tocopheryl succinate) decreases mitotic accumulation in gamma-irradiated human tumor, but not in normal, cells.
• Cicatricial pemphigoid with an upper airway lesion.
• Relative sensitivity of undifferentiated and cyclic adenosine 3',5'-monophosphate-induced differentiated neuroblastoma cells to cyclosporin A: potential role of beta-amyloid and ubiquitin in neurotoxicity.
• Inhibition by protein kinase C of the K(NDP) subtype of vascular smooth muscle ATP-sensitive potassium channel.
• Comparison of the pharmacological properties of EDHF-mediated vasorelaxation in guinea-pig cerebral and mesenteric resistance vessels.
• Renal adenocarcinoma in an owl monkey (Aotus trivirgatus).

Media Releases

Get to know Pulmonologist and Critical Care Physician Dr. William C. Cole II, who serves patients in Lima, Ohio.

Dr. Cole II is a fellowship-trained pulmonologist and critical care physician specializing in the needs of critically ill patients. He is the Director of the ICU at Mercy Health – St. Rita’s Medical Center in Lima, Ohio.

Bringing clinical expertise, his areas of expertise include extracorporeal membrane oxygenation, central line placement, Swan-Ganz catheterization, endobronchial ultrasound bronchoscopy, asthma, chronic obstructive pulmonary disease, pulmonary critical care, pulmonary hypertension, and pulmonology. 

Since 1918, Mercy Health – St. Rita’s Medical Center has been providing quality health care to the people of Lima and west central Ohio. More people prefer St. Rita’s for medical care than any other hospital in the 10-county region. Their comprehensive high-quality medical services include The Henry & Beverly Hawk Vascular & Heart Center at St. Rita’s, St. Rita’s Orthopedic Care Center, trauma and emergency, comprehensive cancer treatment, women’s health, maternity, pediatrics, sports medicine and rehabilitation, behavioral health services, homecare and hospice.

In 1996, Dr. Cole II earned his medical degree from the James H. Quillen College of Medicine at East Tennessee State University. He then went on to perform his residency and fellowship in pulmonary disease at the same educational venue in 1998 and 2000, respectively. 

A member of the American College of Chest Physicians, he is double board-certified in pulmonary disease and internal medicine by the American Board of Internal Medicine (ABIM). The ABIM is a physician-led, non-profit, independent evaluation organization driven by doctors who want to achieve higher standards for better care in a rapidly changing world.

Recognized as a lifetime member of Alpha Omega Alpha, Dr. Cole II has received multiple clinical awards, including the Presidential Award at Covenant Health for his leadership during the Gatlinburg, Tennessee wildfires. 

Pulmonology is a medical specialty that deals with diseases involving the respiratory tract. A pulmonologist is an internal medicine physician who specializes in preventing, diagnosing, and treating conditions and diseases that affect the lungs, bronchial tubes, and the respiratory system (including the nose, pharynx, and throat).

Intensive care medicine, or critical care medicine, is a branch of medicine concerned with the diagnosis and management of life-threatening conditions that may require sophisticated life support and intensive monitoring. A critical care physician treats patients who have any medical or surgical illness or operation that requires critical care support – generally life-threatening major illnesses or operations where high-level life support is required.

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