Dr. Alan W Flake M.D.
Surgeon (Pediatric) | Pediatric Surgery
34th & Civic Center Blvd Children's Hospital Philadelphia PA, 19104About
Dr. Alan Flake practices Pediatric Surgery in Philadelphia, PA. Dr. Flake treats children who have an illness, injury, or disease that requires surgery. Some of the surgical problems seen by pediatric surgeons are often quite different from those commonly seen by adult or general surgeons. Dr. Flakediagnoses, treats, and manages childrens surgical needs such as abnormalities of the groin in childhood and, surgical repair of birth defects, surgical care of tumors, transplantation operations, and endoscopic procedures.
Education and Training
Univ of Ar Coll of Med, Little Rock Ar 1981
University of Arkansas College of Medicine,Little Rock, Ar, United States 1981
Board Certification
SurgeryAmerican Board of SurgeryABS- Pediatric Surgery
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Postnatal booster injections increase engraftment after in utero stem cell transplantation.
- TGF-beta2 is increased after fetal tracheal occlusion.
- In utero bone marrow transplantation induces donor-specific tolerance by a combination of clonal deletion and clonal anergy.
- Persistent postnatal transgene expression in both muscle and liver after fetal injection of recombinant adenovirus.
- Treatment of severe combined immunodeficiency.
- Fetal tracheal occlusion in the rat model of nitrofen-induced congenital diaphragmatic hernia.
- In utero hematopoietic stem cell transplantation: ontogenic opportunities and biologic barriers.
- Homing of human cells in the fetal sheep model: modulation by antibodies activating or inhibiting very late activation antigen-4-dependent function.
- Cotransplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero.
- Maintenance of CD34 expression during proliferation of CD34+ cord blood cells on glycosaminoglycan surfaces.
- A kinetic model for the homing and migration of prenatally transplanted marrow.
- Improvement in hindbrain herniation demonstrated by serial fetal magnetic resonance imaging following fetal surgery for myelomeningocele.
- In utero stem cell transplantation for the treatment of genetic diseases.
- Fetal hematopoietic stem cell transplantation.
- Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector.
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