Dr. Charles A Thornton MD
Neurologist | Vascular Neurology
601 Elmwood Ave Box 278984 Rochester NY, 14642About
Dr. Charles Thornton is a distinguished Neurologist in Rochester, NY. Dr. Thornton specializes in diagnosing, treating, and managing disorders of the brain and nervous system. With expertise in handling complex conditions like epilepsy, multiple sclerosis, and migraines, Dr. Thornton employs advanced techniques and personalized treatment plans to improve patient outcomes. As a neurologist, Dr. Thornton is committed to staying abreast of the latest developments in neurological research and therapies.
Education and Training
Univ Of Ia Coll Of Med- Iowa City Ia 1981
University of Ia Roy J & L Carver Com 1981
Baylor College of Medicine, Houston, Texas 1981
Board Certification
Psychiatry and NeurologyAmerican Board of Psychiatry and NeurologyABPN
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy.
- Computational method for reducing variance with Affymetrix microarrays.
- Myotonic syndromes.
- Molecular fingerprints of inflammatory myopathies.
- Reduced amount of mitochondrial DNA in aged human muscle.
- Gene expression profile of aging in human muscle.
- A muscleblind knockout model for myotonic dystrophy.
- Ribonuclear inclusions in skeletal muscle in myotonic dystrophy types 1 and 2.
- Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women.
- Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons.
- Truncated ClC-1 mRNA in myotonic dystrophy exerts a dominant-negative effect on the Cl current.
- Nuclear RNA foci in the heart in myotonic dystrophy.
- Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy.
- Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy.
- RNA-dominant diseases.
Treatments
- Muscular Dystrophy
- Amyotrophic Lateral Sclerosis (als)
Professional Memberships
- Fellow 2005- American Academy of Neurology
- Member Scientific Advisory Board, Senator Paul D Wellstone Muscular Dystrophy Cooperative Research Center 2006
- Member American Society of Gene Therapy 2008
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