Dr. Adel El Boueiz, MD, MMSc

Areas of expertise and specialization

Faculty Titles & Positions

• Instructor in Medicine Harvard Medical School 2017 - 2019

Awards

• Lebanese Medical Training Awar 2006 American University of Beirut 
• Basic Research Award 2009 American Medical Association 
• Outstanding Teacher Role Model 2012 The Johns Hopkins Hospital 
• Professional Scholarship 2014 American Thoracic Society 
• Clinical Research Award 2015 American Lung Association 
• Abstract Scholarship Award 2015 American Thoracic Society 
• Clinical Research Award 2016 Lung Research Center, Brigham and Women’s Hospital 
• Abstract Scholarship Award 2016 American Thoracic Society 
• Abstract Scholarship Award 2017 American Thoracic Society 
• Chief Research Award 2018 Department of Medicine, Brigham and Women’s Hospital 
• Research Travel Award 2019 Pulmonary Vascular Research Institute 

Professional Memberships

• Alpha Omega Alpha Medical Honor Society  
• American Thoracic Society  
• American College of Chest Physicians  
• The American Society of Human Genetics  

Internships

• American University of Beirut

Fellowships

• Massachusetts General Hospital

Professional Society Memberships

• American Thoracic Society, American College of Chest Physicians, American Society of Human Genetics, American College of Physicians, American Heart Association, American Medical Association

Articles and Publications

• Beydoun MA, Beydoun HA, Boueiz A, Shroff MR, Zonderman AB. Antioxidant status and its association with elevated depressive symptoms among US adults: National Health and Nutrition Examination Surveys 2
• Beydoun MA, Boueiz A, Abougergi MS, Kitner-Triolo MH, Beydoun HA, Resnick SM, O\'Brien R, Zonderman AB. Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of de
• Beydoun MA, Boueiz A, Shroff MR, Beydoun HA, Wang Y, Zonderman AB. Associations among 25-hydroxyvitamin D, diet quality, and metabolic disturbance differ by adiposity in adults in the United States. J
• Boueiz A, Abougergi MS, Noujeim C, Bousamra A, Sfeir P, Zaatari G, Bou-Khalil P. Primary dedifferentiated chondrosarcoma of the lung. South Med J. 2009 Aug; 102(8): 861-863. Cited in PubMed; PMID: 195

What do you attribute your success to?

• The mentors he\'s had.

Favorite professional publications

• The New England Journal of Medicine

Areas of research

COPD is one of the few major causes of death with an increasing mortality, and recently rose to become the third-ranked cause of death in the U.S. Smoking is the major risk factor for COPD, but susceptibility to cigarette smoking is highly variable. A substantial amount of this variability is due to genetic factors. My research has most recently been on the identification of the genetic determinants of emphysema distribution and the development of predictive models of COPD disease progression under the mentorship of Peter Castaldi, MD, MS and Edwin K. Silverman, MD, PhD.

Pulmonary hypertension remains a prevalent source of substantial morbidity and mortality despite recent advances in therapies. Its identification at an early stage is crucial to improve outcomes. Pulmonary vascular morphology in COPD is characterized by distal pruning and proximal dilation and has strong associations with important clinical outcomes. I recently performed a genome-wide association study of pulmonary vascular imaging phenotypes in a subset of subjects with available vascular data in the COPDGene to identify genetic determinants of vascular remodeling in COPD. Although no genome-wide significance was reached, this study highlighted new putative genetic factors and biological pathways that may influence pulmonary vascular remodeling in COPD. Given these promising results, we are now in the process of generating these vascular imaging phenotypes in a larger sample size to increase the power of detection of significant associations. Findings from this study may ultimately improve and personalize therapy in this patient population.

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