Dr. Thomas Pace Johnston M.D.
Pediatrician
101 MANNING DR CHAPEL HILL NC, 27514About
Dr. Thomas Johnston is a pediatrician practicing in Saint Louis, MO. Dr. Johnston is a doctor who specializes in the health care of children. As a pedicatrician, Dr. Johnston diagnoses and treats infections, injuries, diseases and other disorders in children. Pediatricians typically work with infants, children, teenagers and young adults up to age 21. They practice medical care as well as preventative health care. Dr. Johnston can oversee and manage the physical, mental and emotional health of their patients.
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Data provided by the National Library of Medicine- Sex does not seem to influence the formation of aortic lesions in the P-407-induced mouse model of hyperlipidemia and atherosclerosis.
- Poly(L-lysine) as a model drug macromolecule with which to investigate secondary structure and membrane transport, part I: Physicochemical and stability studies.
- Shape imposed by secondary structure of a polypeptide affects its free diffusion through liquid-filled pores.
- Poly(L-lysine) as a model drug macromolecule with which to investigate secondary structure and microporous membrane transport, part 2: diffusion studies.
- An attempt to modulate the microporous diffusion of a model polypeptide by altering its secondary structure.
- Poloxamer 407-mediated alterations in the activities of enzymes regulating lipid metabolism in rats.
- Inducing a change in the pharmacokinetics and biodistribution of poly-L-lysine in rats by complexation with heparin.
- A clinical comparison of calculated versus direct measurement of low-density lipoprotein cholesterol level.
- The P-407-induced murine model of dose-controlled hyperlipidemia and atherosclerosis: a review of findings to date.
- Perfusion of hearts with triglyceride-rich particles reproduces the metabolic abnormalities in lipotoxic cardiomyopathy.
- A randomly coiled, high-molecular-weight polypeptide exhibits increased paracellular diffusion in vitro and in situ relative to the highly ordered alpha-helix conformer.
- Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium.
- The use of mucoadhesive polymers in buccal drug delivery.
- Acute P-407 administration to mice causes hypercholesterolemia by inducing cholesterolgenesis and down-regulating low-density lipoprotein receptor expression.
- Inhibition of pancreatic lipase by poloxamer 407 may provide an adjunct treatment strategy for weight loss.
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