
Dr. Lawrence L Leung M.D.
Hematologist-Oncologist | Hematology & Oncology
3801 Miranda Ave (111) Palo Alto CA, 94304About
Dr. Lawrence Leung is a hematologist oncologist practicing in Palo Alto, CA. Dr. Leung specializes in the diagnosis, treatment and prevention of blood diseases such as anemia, hemophilia, sickle-cell disease, leukemia and lymphoma. Hematologist Oncologists are also trained in the study of cancer and its attack on other organs.
Education and Training
Columbia Univ Coll of Physicians And Surgeons, New York Ny 1975
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM
Internal MedicineAmerican Board of Internal MedicineABIM- Hematology- 1980
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains.
- Dissociation of thrombin's substrate interactions using site-directed mutagenesis.
- A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V.
- An extensive interaction interface between thrombin and factor V is required for factor V activation.
- Immunological consequences of topical bovine thrombin.
- Identification of critical residues on thrombin mediating its interaction with fibrin.
- Structural requirements for the activation of human factor VIII by thrombin.
- Coagulation: consultative hemostasis.
- Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively.
- Thrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammation.
- Molecular cloning of nonsecreted endothelial cell-derived lipase isoforms.
- Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery.
- Molecular mapping of the thrombin-heparin cofactor II complex.
- The cell adhesion molecule CD31 is phosphorylated after cell activation. Down-regulation of CD31 in activated T lymphocytes.
- Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain.
Fellowships
- New York Hospital 1981
Publications
- TransfusionOpen aortic valve replacement in a patient with Glanzmann's thrombasthenia2014
- Proceedings of the tiol Academy of Sciences of the United States of AmTargeting complement component 5a promotes vascular integrity and limits airway remodeling.2013
- JOURL OF BIOLOGICAL CHEMISTRYThrombin-cleaved Fragments of Osteopontin Are Overexpressed in Malignt Glial Tumors2013
- LAB ON A CHIPMicrofluidic impedance cytometer for platelet alysis2013
- JOURL OF BIOLOGICAL CHEMISTRYChemerin158K Protein Is the Domint Chemerin Isoform in Synovial2011
- JOURL OF BIOLOGICAL CHEMISTRYProteolytic Cleavage of Chemerin Protein Is Necessary for Activation to the Active Form, Chem157S2011
- JOURL OF CLINICAL INVESTIGATIONPlasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis2011
- ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGYEnhanced Abdomil Aortic Aneurysm Formation in Thrombin-Activatable Procarboxypeptidase B2010
- JOURL OF THROMBOSIS AND HAEMOSTASISWhat has been learnt from the thrombin-activatable fibrinolysis inhibitor-deficient mouse?2010
- JOURL OF CELLULAR PHYSIOLOGYThrombospondin Type I Domain Containing 7A2010
- JOURL OF THORACIC AND CARDIOVASCULAR SURGERYHeparin-induced thrombosis without thrombocytopenia2010
- JOURL OF BIOLOGICAL CHEMISTRYRegulation of Chemerin Bioactivity by Plasma Carboxypeptidase N2009
- JOURL OF BIOLOGICAL CHEMISTRYThrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites2008
- JOURL OF THROMBOSIS AND HAEMOSTASISEssential thrombin residues for inhibition by protein C inhibitor with the cofactors heparin2007
- JOURL OF BIOLOGICAL CHEMISTRYCrystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery2004
- JOURL OF BIOLOGICAL CHEMISTRYThrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammation2003
- JOURL OF BIOLOGICAL CHEMISTRYThrombin activation of factor XI on activated platelets requires the interaction of factor XI2003
- JOURL OF BIOLOGICAL CHEMISTRYAn extensive interaction interface between thrombin2001
- JOURL OF BIOLOGICAL CHEMISTRYThrombin interacts with thrombomodulin, protein C1999
- JOURL OF BIOLOGICAL CHEMISTRYSELECTION OF A SUPPRESSOR MUTATION THAT RESTORES AFFINITY OF AN OLIGONUCLEOTIDE INHIBITOR FOR1995
- JOURL OF BIOLOGICAL CHEMISTRYFUNCTIOL MAPPING OF THE SURFACE RESIDUES OF HUMAN THROMBIN1995
- tureConversion of thrombin into an anticoagulant by protein engineering1995
- TransfusionOpen aortic valve replacement in a patient with Glanzmann's thrombasthenia2014
- Proceedings of the National Academy of Sciences of the United States oTargeting complement component 5a promotes vascular integrity and limits airway remodeling.2013
- JOURNAL OF BIOLOGICAL CHEMISTRYThrombin-cleaved Fragments of Osteopontin Are Overexpressed in Malignant Glial Tumors2013
- LAB ON A CHIPMicrofluidic impedance cytometer for platelet analysis2013
- JOURNAL OF BIOLOGICAL CHEMISTRYChemerin158K Protein Is the Dominant Chemerin Isoform in Synovial2011
- JOURNAL OF BIOLOGICAL CHEMISTRYProteolytic Cleavage of Chemerin Protein Is Necessary for Activation to the Active Form, Chem157S2011
- JOURNAL OF CLINICAL INVESTIGATIONPlasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis2011
- ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGYEnhanced Abdominal Aortic Aneurysm Formation in Thrombin-Activatable Procarboxypeptidase B2010
- JOURNAL OF THROMBOSIS AND HAEMOSTASISWhat has been learnt from the thrombin-activatable fibrinolysis inhibitor-deficient mouse?2010
- JOURNAL OF CELLULAR PHYSIOLOGYThrombospondin Type I Domain Containing 7A2010
- JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERYHeparin-induced thrombosis without thrombocytopenia2010
- ARTHRITIS AND RHEUMATISMThrombin-Activatable Carboxypeptidase B Cleavage of Osteopontin Regulates Neutrophil Survival2009
- JOURNAL OF BIOLOGICAL CHEMISTRYRegulation of Chemerin Bioactivity by Plasma Carboxypeptidase N2009
- MOLECULAR IMMUNOLOGYRegulation of tissue inflammation by thrombi n-activatable carboxypeptidase B (or TAFI)2008
- JOURNAL OF BIOLOGICAL CHEMISTRYThrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites2008
- JOURNAL OF THROMBOSIS AND HAEMOSTASISEssential thrombin residues for inhibition by protein C inhibitor with the cofactors heparin2007
- BLOODThrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo2007
- CANCER RESEARCHAntiangiogenic antithrombin induces global changes2006
- Hematology / the Education Program of the American Society of HematoloPerioperative evaluation of bleeding diathesis.2006
- JOURNAL OF BIOLOGICAL CHEMISTRYCrystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery2004
- GENOMICSMolecular cloning of nonsecreted endothelial cell-derived lipase isoforms2004
- JOURNAL OF BIOLOGICAL CHEMISTRYThrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammation2003
- JOURNAL OF BIOLOGICAL CHEMISTRYThrombin activation of factor XI on activated platelets requires the interaction of factor XI2003
- BLOODStructural requirements for the activation of human factor VIII by thrombin2002
- THROMBOSIS AND HAEMOSTASISIdentification of critical residues on thrombin mediating its interaction with fibrin2001
- JOURNAL OF BIOLOGICAL CHEMISTRYAn extensive interaction interface between thrombin2001
- JOURNAL OF BIOLOGICAL CHEMISTRYThrombin interacts with thrombomodulin, protein C1999
- CELLULAR AND MOLECULAR LIFE SCIENCESStrategies for development of novel antithrombotics1997
- THROMBOSIS AND HAEMOSTASISModulation of thrombin's procoagulant and anticoagulant properties1997
- JOURNAL OF BIOLOGICAL CHEMISTRYSELECTION OF A SUPPRESSOR MUTATION THAT RESTORES AFFINITY OF AN OLIGONUCLEOTIDE INHIBITOR FOR1995
- JOURNAL OF BIOLOGICAL CHEMISTRYFUNCTIONAL MAPPING OF THE SURFACE RESIDUES OF HUMAN THROMBIN1995
- NatureConversion of thrombin into an anticoagulant by protein engineering1995
Dr. Lawrence L Leung M.D.'s Practice location
Practice At 3801 Miranda Ave (111)
3801 Miranda Ave (111) -Palo Alto, CA 94304Get Direction
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Nearest Hospitals
LUCILE SALTER PACKARD CHILDREN'S HSP AT STANFORDl
725 WELCH ROAD PALO ALTO CA 94304STANFORD HEALTH CAREl
300 PASTEUR DRIVE STANFORD CA 94305MENLO PARK SURGICAL HOSPITALl
570 WILLOW ROAD MENLO PARK CA 94025