Fredric Gaeta, DDS, FAGD

Expert Publications

• High affinity for class II molecules as a necessary but not sufficient characteristic of encephalitogenic determinants.
• MHC interaction and T cell recognition of carbohydrates and glycopeptides.
• ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex.
• Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition.
• On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motifs.
• Effect of pH on MHC class II-peptide interactions.
• Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor.
• Cross-species comparisons of the pharmacokinetics of ibudilast.
• Small peptide inhibitors of smooth muscle myosin light chain kinase.
• Potent peptide inhibitors of smooth muscle myosin light chain kinase: mapping of the pseudosubstrate and calmodulin binding domains.
• Mechanism of cholesteryl ester transfer protein inhibition by a neutralizing monoclonal antibody and mapping of the monoclonal antibody epitope.
• Association of 6-oxo-piperidine-2-carboxylic acid with penicillin V. Production on Penicillium chrysogenum fermentations.
• Major histocompatibility complex class II association and induction of T cell responses by carbohydrates and glycopeptides.
• Thrombin receptor peptide-mediated leukocyte rolling in rat mesenteric venules: roles of P-selectin and sialyl Lewis X.
• Structure--activity relationships of sialyl Lewis x-containing oligosaccharides. 1. Effect of modifications of the fucose moiety.

Media Releases

Get to know Dentist Dr. Fredric Gaeta, who serves patients in Kailua-Kona, Hawaii.

Dr. Gaeta has been serving patients in Kailua-Kona, Hawaii for over 35 years and specializes in aesthetic and restorative dentistry. He has dedicated himself to providing a level of care above and beyond what his patients expect. 

It is his life’s goal to live with purpose, and that shows in both his work and personal life. In creating his patients’ smiles and improving their health, he understands that he also has a direct effect on their outlook on life. He has built a reputation around treating his patients as if they were his own family, providing a variety of dental treatments that are comfortable, safe, and effective. 

Covering many subjects, Dr. Gaeta’s educational history is vast. When combined, it has given him a unique background and perspective in the field of dentistry and on his practice in general. He began at Nassau Community College where he earned his associate’s degree in Chemistry. He then earned his Bachelor of Science degree in Management and Marketing from Long Island University/CW Post College. After that, he continued on to receive his master’s degree in the Philosophy of Natural Science from Hofstra. 

To fulfill his goal of becoming a dentist, Dr. Gaeta attended Georgetown University for his Doctorate of Dental Surgery, and furthered his training by receiving a degree in Anesthesiology and Oral Surgery from New Jersey College of Medicine and Dentistry and UCLA. He is currently pursuing his Master of Science degree in Implantology from Goethe University in Frankfurt, Germany.

As a commitment to his patients and to his own desire to learn, Dr. Gaeta also continues his education on a regular basis, having completed orthodontic training in Europe through the European Program of Graduates in Edgewise Therapy. He has continued his education all over the world, even practicing pediatric dentistry and periodontics in Switzerland for six years prior to opening his own practice in Kailua-Kona. He has also furthered his career in facial rejuvenation and implantology, which includes Botox, Juvederm, PRP, PRF, and CGF. 

Holding fellowship status, he is a Fellow of the American Dental Academy of Anesthesiology and a Fellow of the Academy of General Dentistry (FAGD).

Dentistry, also known as Dental and Oral Medicine, is a branch of medicine that consists of the study, diagnosis, prevention, and treatment of diseases, disorders, and conditions of the oral cavity. Dentists diagnose and treat dental issues and help patients develop better oral hygiene regimens. They clean teeth, correct bite issues, perform surgeries and extractions, and perform other duties to ensure that the teeth and mouth are healthy.  

Outside of his family and dentistry, Dr. Gaeta’s primary joy is traveling around the planet doing Argentine tango. He studies it on every continent, and has a school where he studies and teaches tango all over the world. His school, Echo Tango, is on the island and is the jumping off point for organizing tango events in the area. Another love of his is snowboarding, which he travels globally to do as well. 

Very proud of his family, he has three sons: Vincent, Adrian, and Alexandre. He is fluent in English, Spanish, and French.

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