Dr. Neil L Spector MD
Hematologist-Oncologist | Hematology & Oncology
4101 N Roxboro St Durham NC, 27704Rating
5/5
About
Dr. Neil Spector is a hematologist oncologist practicing in Durham, NC. Dr. Spector specializes in the diagnosis, treatment and prevention of blood diseases such as anemia, hemophilia, sickle-cell disease, leukemia and lymphoma. Hematologist Oncologists are also trained in the study of cancer and its attack on other organs.
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM- 1988
Internal MedicineAmerican Board of Internal MedicineABIM- Medical Oncology- 1989
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Sensitization of tumor cells to fas killing through overexpression of heat-shock transcription factor 1.
- Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine.
- Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways.
- Radioimmunoassay for desmethylimipramine.
- Concurrent exposure to heat shock and H7 synergizes to trigger breast cancer cell apoptosis while sparing normal cells.
- Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016.
- A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon.
- Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects.
- Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas.
- Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells.
- Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers.
- A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer.
- Delivery of a healthy baby after first-trimester maternal exposure to lapatinib.
- Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers.
- A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration.
Awards
- V Foundation Young Investigator Award, V Foundation 1995
- Stanley Glaser Research Foundation Award for Excel, U. Miami School o 1994
- Claudia Adams Barr Investigator in Cancer Research, Dana-Farber Cance 1991
- Wayne Rundles Award for Cancer Research, Duke University School of Me 2008
Professional Memberships
- Member American Association for Cancer Research (AACR)
Fellowships
- Dana-Farber Cancer Inst/Harvard, Bone Marrow Transplantation, MA, USA 1990
- Mass General Hospital/Harvard, Hematology/Medical Oncology, MA, USA 1989
- Medical Oncology and Hematology, Harvard Medical School (Massachusetts) 1986
Dr. Neil L Spector MD's Practice location
Practice At 4101 N Roxboro St
4101 N Roxboro St -Durham, NC 27704Get Direction
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Nearest Hospitals
DUKE UNIVERSITY HOSPITALl
PO BOX 3814 DUMC ERWIN RD DURHAM NC 27710DUKE REGIONAL HOSPITALl
3643 N ROXBORO ROAD DURHAM NC 27704