Dr. Darell Doty Bigner M.D., PH.D.
Neurologist | Neurology
Duke University Medical Ctr Msrb-1, Room 177, Re Durham NC, 27710About
Dr. Darell Bigner is a distinguished Neurologist in Durham, NC. Dr. Bigner specializes in diagnosing, treating, and managing disorders of the brain and nervous system. With expertise in handling complex conditions like epilepsy, multiple sclerosis, and migraines, Dr. Bigner employs advanced techniques and personalized treatment plans to improve patient outcomes. As a neurologist, Dr. Bigner is committed to staying abreast of the latest developments in neurological research and therapies.
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Dosimetry of 131I-labeled 81C6 monoclonal antibody administered into surgically created resection cavities in patients with malignant brain tumors.
- Molecular pathogenesis of malignant gliomas.
- Irinotecan therapy in adults with recurrent or progressive malignant glioma.
- Treatment of neoplastic meningitis with intrathecal temozolomide.
- Astatine-211 labeling of internalizing anti-EGFRvIII monoclonal antibody using N-succinimidyl 5-[211At]astato-3-pyridinecarboxylate.
- 125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts.
- Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization.
- Radiotoxicity of systemically administered 211At-labeled human/mouse chimeric monoclonal antibody: a long-term survival study with histologic analysis.
- Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1.
- Preparation and characterization of anti-tenascin monoclonal antibody-streptavidin conjugates for pretargeting applications.
- Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines.
- Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma.
- Dosimetry and dose-response relationships in newly diagnosed patients with malignant gliomas treated with iodine-131-labeled anti-tenascin monoclonal antibody 81C6 therapy.
- Intrathecal busulfan treatment of human neoplastic meningitis in athymic nude
- Schedule-dependent activity of irinotecan plus BCNU against malignant glioma xenografts.
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