Dr. Jack Wolfe Singer MD
Hematologist-Oncologist | Hematology & Oncology
Harborview Medical Center 325 9th Ave Seattle WA, 98104Rating
5/5
About
Dr. Jack Singer is a hematologist oncologist practicing in Seattle, WA. Dr. Singer specializes in the diagnosis, treatment and prevention of blood diseases such as anemia, hemophilia, sickle-cell disease, leukemia and lymphoma. Hematologist Oncologists are also trained in the study of cancer and its attack on other organs.
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Synthesis and in vivo antitumor activity of poly(l-glutamic acid) conjugates of 20S-camptothecin.
- Poly-(L)-glutamic acid-paclitaxel (CT-2103) [XYOTAX], a biodegradable polymeric drug conjugate: characterization, preclinical pharmacology, and preliminary clinical data.
- Lysophosphatidic acid acyltransferase-beta: a novel target for induction of tumour cell apoptosis.
- Inhibition of lysophosphatidic acid acyltransferase beta disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells.
- Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma.
- Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-beta.
- Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells.
- Paclitaxel poliglumex (XYOTAX; CT-2103): an intracellularly targeted taxane.
- Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.
- Induction of apoptosis using inhibitors of lysophosphatidic acid acyltransferase-beta and anti-CD20 monoclonal antibodies for treatment of human non-Hodgkin's lymphomas.
- Diamino-C,N-diarylpyridine positional isomers as inhibitors of lysophosphatidic acid acyltransferase-beta.
- Paclitaxel poliglumex (XYOTAX, CT-2103): a macromolecular taxane.
- Substrate specificity of lysophosphatidic acid acyltransferase beta -- evidence from membrane and whole cell assays.
- In vitro and in vivo metabolism of paclitaxel poliglumex: identification of metabolites and active proteases.
- Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer-drug conjugate.
Dr. Jack Wolfe Singer MD's Practice location
Practice At Harborview Medical Center 325 9th Ave
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Nearest Hospitals
HARBORVIEW MEDICAL CENTERl
325 9TH AVENUE SEATTLE WA 98104SWEDISH MEDICAL CENTERl
747 BROADWAY SEATTLE WA 98122VIRGINIA MASON MEDICAL CENTERl
925 SENECA ST SEATTLE WA 98101