Dr. Stuart H. Orkin MD
Hematologist (Pediatric) | Pediatric Hematology-Oncology
44 Binney St Dana Building Rm 164 Boston MA, 02115Rating
1/5
About
Dr. Orkin received his MD in 1972 from Harvard Medical School, followed by postdoctoral research at the National Institutes of Health and clinical training in pediatrics and hematology-oncology at Chi ...
Education and Training
Harvard Medical School 1972
Board Certification
PediatricsAmerican Board of PediatricsABP
DermatologyAmerican Board of DermatologyABD
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex.
- Intersections between blood cell development and leukemia genes.
- Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice.
- Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene.
- Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system.
- Guanine-adenine ligation-mediated polymerase chain reaction in vivo footprinting.
- GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression.
- Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.
- Apoptosis. Cutting red-cell production.
- An essential role in liver development for transcription factor XBP-1.
- Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos.
- Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1.
- FOG acts as a repressor of red blood cell development in Xenopus.
- ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation.
- A downstream element in the human beta-globin promoter: evidence of extended sequence-specific transcription factor IID contacts.
Awards
- 2005 AAMC Award for Distinguished Research in Medical Sciences
- 1993 Warren Alpert Foundation Prize
- 1992 Member, American Academy of Arts and Sciences
- 1991 Member, National Academy of Sciences
- American Society of Hematology 1986 Dameshek Award
Treatments
- Cancer, Blood Disorders
Fellowships
- Boston Children's Hospital, Pediatric Hematology/Oncology 1978
- Boston Children's Hospital - Boston, MA
- Boston Children's Hospital, Fellow:Pediatric Hematology-Oncology 1976
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