Dr. Donald Allan Mcclain M.D., PH.D.
Endocrinology-Diabetes | Endocrinology, Diabetes & Metabolism
1 MEDICAL CENTER BLVD WINSTON SALEM NC, 27157About
Dr. Donald Mcclain practices Endocrinology in Salt Lake City, UT. Dr. Mcclain specializes in preventing, diagnosing, and treating diseases related to hormone imbalance, and the bodys glands in the endocrine system. Endocrinologists are trained and certified to treat a variety of conditions, including menopause, diabetes, infertility, and thyroid disorders, among many others. Dr. Mcclain examines patients, determines means of testing, diagnoses, and decides the best treatment methods.
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM- Endocrinology and Metabolism
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Hexosamines as mediators of nutrient sensing and regulation in diabetes.
- Transgenic mice overexpressing the rate-limiting enzyme for hexosamine synthesis in skeletal muscle or adipose tissue exhibit total body insulin resistance.
- Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine.
- Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance.
- Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis.
- Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity.
- Adipocytes with increased hexosamine flux exhibit insulin resistance, increased glucose uptake, and increased synthesis and storage of lipid.
- Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells.
- Chronic hexosamine flux stimulates fatty acid oxidation by activating AMP-activated protein kinase in adipocytes.
- Recipes for creating animal models of diabetic cardiovascular disease.
- Utility of ultrasound-guided fine-needle aspiration of parathyroid adenomas for localization before minimally invasive parathyroidectomy.
- PAS kinase is required for normal cellular energy balance.
- Increased glucose disposal and AMP-dependent kinase signaling in a mouse model of hemochromatosis.
- Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase.
- Protein modification by O-linked GlcNAc reduces angiogenesis by inhibiting Akt activity in endothelial cells.
Dr. Donald Allan Mcclain M.D., PH.D.'s Practice location
Donald McClain
30 N. 2030 East Division Of Endocrin -Salt Lake City, UT 84132Get Direction
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Nearest Hospitals
UNIVERSITY HEALTH CARE/UNIV HOSPITALS AND CLINICSl
50 NORTH MEDICAL DRIVE SALT LAKE CITY UT 84132PRIMARY CHILDRENS HOSPITALl
100 NORTH MARIO CAPECCHI DRIVE SALT LAKE CITY UT 84113SHRINERS HOSPITALS FOR CHILDREN - S L Cl
FAIRFAX ROAD AT VIRGINIA STREET SALT LAKE CITY UT 84103NOVANT HEALTH FORSYTH MEDICAL CENTERl
3333 SILAS CREEK PARKWAY WINSTON-SALEM NC 27103NOVANT HEALTH MEDICAL PARK HOSPITALl
1950 S HAWTHORNE RD WINSTON-SALEM NC 27103