Dr. Carolyn Salafia

Expert Publications

• Histologic distribution and biochemical properties of alpha 1-microglobulin in human placenta.
• Decidual and vascular pathophysiology in pregnancy compromise.
• Biophysical profile in predicting acute ascending infection in preterm rupture of membranes before 32 weeks.
• Chronic intrauterine bleeding and fetal growth at less than 32 weeks of gestation.
• Torsade de pointes in a child with acute rheumatic fever.
• A perinatal pathology view of preterm labor.
• Antenatal corticosteroids and placental histology in preterm birth.
• Shortened gestational age following multifetal pregnancy reduction: can chronic placental inflammation be the explanation?
• Recurrent obstetric complications: how placental pathology can contribute to cost-effective clinical evaluation and a rational clinical care plan.
• Relationship between the extent of histologic villous mineralization and stillbirth in aneuploid and euploid fetuses.
• Clinical pathology--a workshop report.
• National Institute on Drug Abuse Conference report on placental proteins, drug transport, and fetal development.
• Gender differences of placental dysfunction in severe prematurity.
• The twin placenta: framework for gross analysis in fetal origins of adult disease initiatives.
• Placental pathology of idiopathic intrauterine growth retardation at term.

Media Releases

Enhancing Clinical Insights into Pregnancy Complications

Dr. Carolyn M. Salafia, M.D., a board-certified expert in Anatomic and Clinical Pathology with a subspecialty in Pediatric Pathology, is making groundbreaking strides in the field of reproductive pathology. With extensive academic experience at notable institutions such as Georgetown University Medical Center, Albert Einstein College of Medicine, and Columbia University College of Physicians and Surgeons, Dr. Salafia is dedicated to advancing the understanding of pregnancy complications and loss.

Dr. Salafia earned her Bachelor of Arts degree from Dartmouth College and her Doctor of Medicine from Duke University School of Medicine. Following her education, she completed a residency in Anatomic and Clinical Pathology at the Yale-affiliated community hospitals of St Raphael and Danbury Hospital. It was during this time that she began her impactful research on placental pathology in low-risk populations, laying the groundwork for her current focus on reproductive and developmental pathology.

For over fifteen years, Dr. Salafia has concentrated her clinical practice and research on the complexities of reproductive health. “The developmental pathologist must use the tools of tissue study to assist clinical caregivers in determining the causes of pregnancy compromise,” Dr. Salafia explains. She emphasizes the importance of distinguishing between inherent vulnerabilities in human reproduction and those that necessitate clinical intervention. Historically, pathologists played a crucial role in confirming pregnancies, but advancements in obstetric ultrasound and sensitive HCG tests have shifted the focus toward understanding the causes of pregnancy loss.

Recognized as one of the few pathologists specializing in reproductive pathology in the United States, Dr. Salafia’s expertise has been acknowledged with a prestigious Patient-Oriented Research (POR) Scholarship at the Joseph L. Mailman School of Public Health at Columbia University. This full-time graduate program enables her to refine her clinical diagnoses and address pressing questions concerning recurrence risks and treatment efficacy for women experiencing pregnancy complications.

Dr. Salafia states, “Our current methods of obstetric risk assessment complicate our ability to honestly assess the effects of treatment and may cause many women to be exposed to unnecessary treatment and worry.” She advocates for an improved understanding of recurrence risk and the development of tailored treatments that address specific causes of pregnancy loss.

In collaboration with her clinical colleagues, Dr. Salafia is spearheading surveillance and treatment trials targeting vascular issues associated with early and late pregnancy complications. Her commitment to multidisciplinary collaboration extends to a wide range of obstetric, reproductive endocrine, genetic, and pathology experts, ensuring a comprehensive approach to her research.

With a prolific publication record that includes over 100 original manuscripts, book chapters, and 200 abstracts, Dr. Salafia has garnered support from both federal and private funding agencies. Her current NIH-sponsored training aims to revolutionize placental evaluation methods, enhancing the understanding of gestational pathology’s role in neurodevelopmental disorders. Among her numerous accolades, she received a K23 Mentored Mid-Career Development Award from the National Institutes of Mental Health, further solidifying her dedication to advancing reproductive health research.

Dr. Salafia’s innovative spirit was also nurtured during her fellowship with the National Science Foundation at the Institute of Pure and Applied Mathematics at UCLA from 2007 to 2009. There, she led a multidisciplinary team to develop novel measures of placental growth and disease states, including acute intraamniotic infection.

As Dr. Carolyn M. Salafia continues to push the boundaries of reproductive pathology, her work promises to illuminate the complexities of pregnancy health and pave the way for improved clinical practices. Her passion for research and patient care epitomizes the vital role of pathologists in the evolving landscape of reproductive medicine.

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