Dr. Jason Littleton, MD

Expert Publications

• Effects of prolonged exposure to ethanol in vivo on functional parameters and sensitivity to nitrendipine in the isolated rat heart.
• Effect of calcium, Bay K 8644, and reduced perfusion on basic indices of myocardial function in isolated hearts from rats after prolonged exposure to ethanol.
• Increased sensitivity to damaging effects of hypoxia and anoxia of isolated hearts from rats after prolonged exposure to ethanol: apparent protection by nitrendipine.
• The experimental approach to alcoholism.
• Damaging effects of the calcium paradox are reduced in isolated hearts from ethanol-dependent rats: paradoxic effects of dihydropyridine drugs.
• Chronic, but not acute, nicotine exposure attenuates ethanol withdrawal-induced hippocampal damage in vitro.
• Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex.
• In vitro effects of ethanol withdrawal and spermidine on viability of hippocampus from male and female rat.
• Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex.
• Chronic nicotine exposure reduces N-methyl-D-aspartate receptor-mediated damage in the hippocampus without altering calcium accumulation or extrusion: evidence of calbindin-D28K overexpression.
• Role of polyamines and NMDA receptors in ethanol dependence and withdrawal.
• Nicotine exposure reduces N-methyl-D-aspartate toxicity in the hippocampus: relation to distribution of the alpha7 nicotinic acetylcholine receptor subunit.
• Proceedings: Alterations in dopamine uptake in rat corpus striatum induced by combinations of stress and delta8-tetrahydrocannabinol (delta8-THC).
• Hippocampal CA1 region neurodegeneration produced by ethanol withdrawal requires activation of intrinsic polysynaptic hippocampal pathways and function of N-methyl-D-aspartate receptors.
• (-)-nicotine ameliorates corticosterone's potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity.

Media Releases

Personalized Care Meets Modern Wellness at Littleton Concierge Medicine

Dr. Jason Littleton, a board-certified family physician and recognized leader in healthcare, is proud to offer innovative concierge healthcare services in and around Central Florida. As the CEO of Littleton Concierge Medicine and the Chairman of the Department of Family Medicine at Orlando Regional Medical Center, he is committed to enhancing the health and well-being of his patients through personalized medicine and a focus on preventive care.

His approach to healthcare emphasizes the importance of personal attention and lifestyle choices that promote optimal health, energy, and happiness. “In today’s fast-paced world, it’s essential to prioritize our health by making smart lifestyle choices,” says Dr. Littleton. “I aim to provide my patients with practical, personalized guidance that fits seamlessly into their busy lives, empowering them to make nutritious choices and stay active.”

A graduate of Michigan State University College of Human Medicine, he also holds a Bachelor of Science in Biology from the University of Michigan. His dedication to compassionate care has earned him numerous accolades, including National Doctor’s Day Recognition for excellence in patient care at St. Mary’s Hospital in Grand Rapids, MI, and the Resident Teacher Award during his residency in family medicine.

In addition to his clinical work, Dr. Littleton is a sought-after motivational health speaker and media personality. He has made appearances on popular national television programs, including the Dr. Oz Show and The Dr. Nandi Show, and has contributed to various renowned publications such as Redbook, Prevention, and Orlando Style. As a regular medical contributor on Fox35 Orlando News, he provides valuable insights and updates on current health topics to the Central Florida community.

Outside of his medical practice, he enjoys quality time in the sunshine with his wife Rheami and their daughter Reagan Elizabeth. The family frequently visits Central Florida’s theme parks, beaches, and attractions, and they actively participate in their local church, Dream Life Center, where they serve in the ministry.

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