Karen C. Rosenspire, MD, PhD

Expert Publications

• Myocardial extraction of teboroxime: effects of teboroxime interaction with blood.
• PET scanning with hydroxyephedrine: an approach to the localization of pheochromocytoma.
• Direct analysis of whole blood by internal surface reversed-phase chromatography: an examination of the binding and metabolism of technetium dioxime complexes.
• Short-term metabolic fate of L-[13N]glutamate in the Walker 256 carcinosarcoma in vivo.
• Methods for the enzymatic synthesis of tyrosine and phenylalanine labeled with nitrogen-13.
• Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging.
• Metabolic fate of [13N]ammonia in human and canine blood.
• Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: a false transmitter agent for heart neuronal imaging.
• Radioiodinated benzodiazepines: agents for mapping glial tumors.
• Short-term metabolic fate of 13N-labeled glutamate, alanine, and glutamine(amide) in rat liver.
• High-performance liquid chromatographic on-line flow-through radioactivity detector system for analyzing amino acids and metabolites labeled with nitrogen-13.
• Enzymatic syntheses of carbamyl phosphate, L-citrulline, and N-carbamyl L-aspartate labeled with either 13N or 11C.
• Comparison of four methods of analysis of 99mTc pyrophosphate uptake in rheumatoid arthritic joints.
• Investigation of the metabolic acitivity of bone in rheumatoid arthritis.
• Boronic acid adducts of technetium dioxime (BATO) complexes derived from quinuclidine benzilate (QNB) boronic acid stereoisomers: syntheses and studies of their binding to the muscarinic acetylcholine receptor.

Media Releases

Get to know Radiologist Dr. Karen C. Rosenspire, who serves patients in Philadelphia, Pennsylvania.

Dr. Rosenspire is a board-certified radiologist who currently serves as an Assistant Professor of Clinical Radiology at the Department of Radiology/ Division of Nuclear Medicine and Clinical Molecular Imaging at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, Pennsylvania.

The Perelman School of Medicine at the University of Pennsylvania consistently ranks among the top five in US News and World Report’s rankings of research-oriented medical schools. Its mission is to advance knowledge and improve health through research, patient care, and the education of trainees in an inclusive culture that embraces diversity, fosters innovation, stimulates critical thinking, supports lifelong learning, and sustains the University’s legacy of excellence.

After earning her Bachelor of Arts degree in Chemistry and Biology from Eastern College in St. Davids, Pennsylvania, Dr. Rosenspire went on to obtain her Doctorate degree in Biophysics from the State University of New York at Buffalo in 1980. 19 years later, in 1999, she earned her medical degree from the Wayne State School of Medicine in Detroit, Michigan. The doctor’s postgraduate training encompassed an internship and a residency in radiology at Henry Ford Hospital in Detroit, a fellowship in nuclear medicine at the University of Michigan in Ann Arbor, as well as a fellowship in women’s imaging at Henry Ford Hospital. 

Following her education, she became board-certified in diagnostic radiology by the American Board of Radiology, which is a non-profit physician-led organization that oversees the certification and ongoing professional development of specialists in diagnostic radiology, radiation oncology, and medical physics. She also became board-certified in nuclear medicine by the American Board of Nuclear Medicine, which certifies physicians as specialists in the practice of nuclear medicine.

Radiology is a medical specialty that uses medical imaging to diagnose and treat diseases within the human body. Radiologists are medical doctors who specialize in diagnosing and treating injuries and diseases using medical imaging procedures, such as exams and tests, X-rays, computed tomography, magnetic resonance imaging, nuclear medicine, mammography, positron emission tomography, and ultrasound.

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