![Michelle S. Bradbury, MD, PhD, Radiologist](/doctor_images/3/3a/291088.jpg?v=de65)
Michelle S. Bradbury, MD, PhD
Radiologist | Neuroradiology
1300 York Ave New York New York, 10065About
I am a Professor and Endowed Chair of Imaging Research in the Department of Radiology at Weill Cornell Medical College and serve as the Director of the Molecular Imaging Innovations Institute and the Perioperative Imaging and Engineered Technologies Program for Cancer Treatment. In addition, I am Head of Cross-Campus Research Collaborations and Innovations within the Sandra and Edward Meyer Cancer Center. As a clinician-scientist with more than 20 years of experience in molecular imaging and radiological sciences, I have led multi-disciplinary efforts focused on the co-development and translation of molecularly-targeted, ultrasmall fluorescent core-shell silica nanoparticles (C' dots) to the clinic for image-guided surgical applications and drug delivery. I previously served as PI on clinical trials and as a Co-Director of the NCI U54 MSK-Cornell Center for Translation of Cancer Nanomedicines. My laboratory is currently engaged in more recent studies investigating multi-therapeutic (adjuvant) properties of newer generation C’ dots for treating immune suppressive tumor microenvironments.
Education and Training
George Washington University MD 1997
Mass Institute of Technology Ph.D. 1993
Univ of Maryland M.S. 1986
University of Pennsylvania B.A. 1982
Board Certification
American Board of Radiology
Neuroradiology (Radiology)
RadiologyAmerican Board of RadiologyABR
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Optical bioluminescence imaging of human ES cell progeny in the rodent CNS.
- Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma.
- Serial monitoring of human systemic and xenograft models of leukemia using a novel vascular disrupting agent.
- Fluorine-labeled dasatinib nanoformulations as targeted molecular imaging probes in a PDGFB-driven murine glioblastoma model.
- Multicompartment mesoporous silica nanoparticles with branched shapes: an epitaxial growth mechanism.
- Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe.
- Ultrasmall integrin-targeted silica nanoparticles modulate signaling events and cellular processes in a concentration-dependent manner.
- Ultrasmall dual-modality silica nanoparticle drug conjugates: Design, synthesis, and characterization.
- Intraoperative mapping of sentinel lymph node metastases using a clinically translated ultrasmall silica nanoparticle.
- Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth.
- Melanocortin-1 Receptor-Targeting Ultrasmall Silica Nanoparticles for Dual-Modality Human Melanoma Imaging.
- Target-or-Clear Zirconium-89 Labeled Silica Nanoparticles for Enhanced Cancer-Directed Uptake in Melanoma: A Comparison of Radiolabeling Strategies.
- Cancer-Targeting Ultrasmall Silica Nanoparticles for Clinical Translation: Physicochemical Structure and Biological Property Correlations.
Areas of expertise and specialization
Faculty Titles & Positions
- Director, Molecular Imaging Innovations Institute Weill Cornell Medicine 2023 - Present
- Director, Perioperative Imaging & Engineered Technologies for Oncology Weill Cornell Medicine 2023 - Present
- Head, Cross-Campus Research Collaborations and Innovations Weill Cornell Medicine 2023 - Present
- Director, Intraoperative Imaging Memorial Sloan Kettering Cancer Center 2014 - 2023
- Co-Chair Innovations Technology Team Memorial Sloan Kettering Cancer Center 2014 - 2023
- Endowed Chair of Imaging Research Weill Cornell Medicine 2023 - Present
- Professor of Radiology Weill Cornell Medicine 2023 - Present
Awards
- Recipient, 9th Annual Distinguished Investigator Award 2020 Academy for Radiology and Biomedical Imaging Research
Treatments
- Neuroradiology
Professional Memberships
- American Medical Association
- American Society of Clinical Oncology
- Radiological Society of North America
- American Society of Neuroradiology
- American Board of Radiology
- Sigma Xi
- American Association for Cancer Research
Charities and Philanthropic Endeavors
- The John and Michelle Bradbury Medical Foundation
Internships
- Surgery, Bowman-Gray School of Medicine Wake-Forest Baptist Medical Center
Fellowships
- Neuroradiology, Bowman-Gray School of Medicine Wake-Forest Baptist Medical Center Molecular Imaging for Oncology, Memorial Sloan Kettering
Professional Society Memberships
- Sigma XiAmerican Chemical SocietyAmerican Association for the Advancement of ScienceWorld Molecular Imaging Congress
Favorite Place to Vacation
- U.K., Nantucket
Areas of research
Nanomedicine (translational/clinical), Nanoengineering, Drug Delivery, Tumor Microenvironment, Image-guided Surgery, Radiotherapy, Oncology, Molecular Imaging, Molecular/Cellular Biology
Michelle S. Bradbury, MD, PhD's Practice location
Weill Cornell Medicine
1300 York Ave -New York, New York 10065Get Direction
Michelle S. Bradbury, MD, PhD's reviews
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Get to know physician-scientist Dr. Michelle S. Bradbury, a Neuroradiologist who serves patients in New York, New York.
Board-certified neuroradiologist, Dr. Bradbury is Director of the Molecular Imaging Innovations Institute and the Perioperative Imaging and Engineered Technologies Program for Oncology. She is also Head of Cross-Campus Research Collaborations and Innovations with a particular interest in the Cornell Institute for Engineering Innovations in Medicine Program, among others, within the Sandra and Edward Meyer Cancer Center.
Throughout her academic career, she earned her medical degree from the George Washington University School of Medicine, and received her PhD from the Massachusetts Institute of Technology. She then went on to complete her residency in diagnostic radiology and her fellowship in neuroradiology at the Bowman Gray School of Medicine / Wake Forest Baptist Medical Center.
In pursuit of clinical excellence, Dr. Bradbury is board-certified in diagnostic radiology by the American Board of Radiology (ABR), with a Certificate of Added Qualification (CAQ) in Neuroradiology. The ABR is a not-for-profit physician-led organization that oversees the certification and ongoing professional development of specialists in diagnostic radiology, Neuroradiology, Interventional Radiology, Radiation Oncology, and Medical Physics.
Dr. Bradbury is an active member of the American Medical Association, the American Society of Clinical Oncology, the Radiological Society of North America, the American Society of Neuroradiology, Sigma Xi, and the American Association for Cancer Research.
As a physician-scientist with long-standing expertise in Molecular Imaging, Therapeutics, and the Radiological Sciences, she previously served as Co-Director of a National Cancer Institute funded Memorial Sloan Kettering-Cornell Center for Translation of Cancer Nanomedicines. The Center advanced groundbreaking work in the design and translation of molecularly targeted, ultrasmall core-shell silica nanoparticles to the clinic for image-guided surgical and therapeutic applications in cancer.
These minute fluorescent particles, when tagged with radiolabels, enable visualization of diseased tissues using multimodal PET and optical imaging approaches that offer a safer and more effective means of detecting and treating tumor cells and metastases within the body without associated toxicity.
Extending her research into the realm of surgical applications, Dr. Bradbury is actively involved in utilizing image-guided surgical applications and particle tracers to assess the spread of cancer cells to lymph nodes and along surgical margins in collaboration with several subsurgical specialities, such as Otolaryngology and Urology. Moreover, her work encompasses the attachment of therapeutic drugs to nanoparticles, bridging the gap between research and clinical trials in collaboration with the Department of Surgery. In addition, the particles used for these studies are intrinsically therapeutic and have been found to enhance anti-cancer proinflammatory responses and augment anti-tumor immunity in immunosuppressive tumor microenvironments.
Within the Brain Tumor Center, she has been at the forefront of investigating the use of small molecule drugs attached to particles for treating brain tumors. This innovative approach holds promise for enhanced penetration through the blood-brain barrier, potentially reaching tumor cells more effectively than conventional drugs and larger-size therapeutic platforms. Simultaneously, she explores novel ways to integrate MRI findings with PET scanning data to deepen our understanding of the molecular biology of brain tumors.
Throughout her research endeavors, Dr. Bradbury’s overarching goal is clear: to develop novel approaches that enhance the precision of targeting and treating tumor cells, as well as regulating the tumor microenvironment. By improving the diagnosis, staging, and treatment of cancers, she aspires to contribute to advancements that ultimately elevate survival rates and prognosis for patients.
Neuroradiology is a subspecialty of radiology focusing on the diagnosis and characterization of abnormalities of the central and peripheral nervous system, spine, and head and neck using neuroimaging techniques. Neuroradiologists are doctors who focus on diagnosing conditions of the spine, neck, head, and central nervous system. They use medical equipment, such as computed tomography or magnetic resonance imaging machines, to identify problems.
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