Dr. Mani S. Mahadevan M.D.
Pathologist | Anatomic Pathology & Clinical Pathology
3rd Hospital Dr Charlottesville VA, 22908About
Dr. Mani Mahadevan is a pathologist practicing in Charlottesville, VA. Dr. Mahadevan is a doctor who specializes in the study of bodily fluids and tissues. As a pathologist, Dr. Mahadevan can help your primary care doctor make a diagnosis about your medical condition. Dr. Mahadevan may perform a tissue biopsy to determine if a patient has cancer, practice genetic testing, and complete a number of laboratory examinations. Pathologists can also perform autopsies which can determine a persons cause of death and gain information about genetic progression of a disease.
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Cis and trans effects of the myotonic dystrophy (DM) mutation in a cell culture model.
- Myotonic dystrophy: the role of the CUG triplet repeats in splicing of a novel DMPK exon and altered cytoplasmic DMPK mRNA isoform ratios.
- The myotonic dystrophy expanded CUG repeat tract is necessary but not sufficient to disrupt C2C12 myoblast differentiation.
- Mutant DMPK 3'-UTR transcripts disrupt C2C12 myogenic differentiation by compromising MyoD.
- Myogenic defects in myotonic dystrophy.
- Genotype-phenotype correlations: assessing the influence of sequence variants on the clinical phenotype.
- Woodchuck post-transcriptional element induces nuclear export of myotonic dystrophy 3' untranslated region transcripts.
- Factor V null mutation affecting the Roche LightCycler factor V Leiden assay.
- RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression.
- Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: two individual consequences of CUG trinucleotide repeats.
- The effect of myotonic dystrophy transcript levels and location on muscle differentiation.
- Genetics. Exposing a DUX tale.
- Myotonic muscular dystrophy, RNA toxicity, and the brain: trouble making the connection?
- Therapeutics development in myotonic dystrophy type 1.
- The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicing.
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