Dr. David J Kusner MD PHD
Infectious Disease Specialist | Infectious Disease
540 E JEFFERSON ST IOWA CITY IA, 52245About
Dr. David Kusner is an infectious disease specialist practicing in Iowa City, IA. Dr. Kusner specializes in infections that are difficult to diagnose or unresponsive to treatments, such as HIV or airborne infections from a foreign country. Infectious disease specialists usually work with conditions that are not treatable by a primary physician but it is important to keep contact with the primary physician in order to receive information about the patients history and for deciding which diagnostic tests are appropriate.
Education and Training
Harvard Med Sch, Boston Ma 1985
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM
Provider Details
Expert Publications
Data provided by the National Library of Medicine- ATP-induced killing of virulent Mycobacterium tuberculosis within human macrophages requires phospholipase D.
- Inhibition of Ca(2+) signaling by Mycobacterium tuberculosis is associated with reduced phagosome-lysosome fusion and increased survival within human macrophages.
- In vitro and in vivo macrophage function can occur independently of SLP-76.
- Mycobacterium tuberculosis phagosomes exhibit altered calmodulin-dependent signal transduction: contribution to inhibition of phagosome-lysosome fusion and intracellular survival in human macrophages.
- ATP stimulates human macrophages to kill intracellular virulent Mycobacterium tuberculosis via calcium-dependent phagosome-lysosome fusion.
- Regulation of phospholipase D activity by actin. Actin exerts bidirectional modulation of Mammalian phospholipase D activity in a polymerization-dependent, isoform-specific manner.
- Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase.
- Evolutionary conservation of physical and functional interactions between phospholipase D and actin.
- Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis.
- Mechanisms of mycobacterial persistence in tuberculosis.
- Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis.
- Calmodulin kinase II regulates the maturation and antigen presentation of human dendritic cells.
- Phospholipase D1 regulates phagocyte adhesion.
- Assay of phospholipase D activity in cell-free systems.
- MHC Class II levels and intracellular localization in human dendritic cells are regulated by calmodulin kinase II.
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