Dr. Israel David Goldman M.D.
Oncologist | Medical Oncology
1300 Morris Park Ave Cancer Center, Chani Bronx NY, 10461About
Dr. Israel Goldman is an oncologist practicing in Bronx, NY. Dr. Goldman specializes in the care and treatment of patients with cancer. As an oncologist, Dr. Goldman manages and oversees the treatment of a cancer patient after he or she has been diagnosed with the disease. Oncologists will care for their patients throughout the course of the disease. Types of oncologists include medical oncologists, surgical oncologists, radiation oncologists, gynecologic oncologists, pediatric oncologists and hematologist oncologists.
Education and Training
Center Of Chicago / Pritzker School Of Medicine 1962
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier function.
- Mechanism of action of methotrexate. IV. Free intracellular methotrexate required to suppress dihydrofolate reduction to tetrahydrofolate by Ehrlich ascites tumor cells in vitro.
- Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis.
- Inhibitory effects of prostaglandin A1 on membrane transport of folates mediated by both the reduced folate carrier and ATP-driven exporters.
- Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier.
- Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates.
- Role of the amino acid 45 residue in reduced folate carrier function and ion-dependent transport as characterized by site-directed mutagenesis.
- Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells.
- Rapid determination of membrane transport parameters in adherent cells.
- The reduced folate carrier in L1210 murine leukemia cells is a 58-kDa protein.
- Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase.
- Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier.
- The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate.
- Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells.
- Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs.
Fellowships
- Medical Oncology, National Cancer Institute, Bethesda, MD USA 1969
Dr. Israel David Goldman M.D.'s Practice location
Israel Goldman
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