Dr. Susan P. Perrine MD, SM, MMS
Pediatrician
About
Dr. Susan P. Perrine is a Pediatric Hematologist Oncologist, a specialty for care and research on blood diseases and cancer in children. She has conducted long term research in translational medicine to discover and develop therapies from the laboratory into international clinical trials in sickle cell disease, thalassemias, viral associated lymphomas, and novel agents to treat low blood counts.
Dr. Perrine trained at Harvard School of Public Health, Tufts University School of Medicine, and Boston Children's Hospital, and served on the medical staff of Stanford Children's Hospital, UCSF Benioff Children's Hopsital Oakland, Boston Medical Center, and Tufts Children's Hospital. A Founder of 3 biotechnology companies, she has held roles of Chief Scientific Officer, VP Clinical Affairs, President and Chief Medical Officer, and consults on clinical development programs in Hematology Oncology. A Professor of Pharmacology and Experimental Therapeutics, Medicine, and Pediatrics at Boston University School of Medicine for 30 years, she has coninuously held NIH grants and is inventor on > 20 patents.
Education and Training
Tufts Univ. School of Medicine MD 1976
Harvard Sch of Public Health SM 1972
Rutgers Univ Sch of Medicine MMS 1974
Board Certification
Pediatric Hematology-Oncology (Pediatrics)
PediatricsAmerican Board of PediatricsABP
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo.
- Biochemical effect of intravenous arginine butyrate in X-linked adrenoleukodystrophy.
- Sickle cell anemia is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels.
- Enhancement of growth and survival and alterations in Bcl-family proteins in beta-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives.
- Fetal globin induction--can it cure beta thalassemia?
- Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.
- Novel short chain fatty acids restore chloride secretion in cystic fibrosis.
- Identification of novel small-molecule inducers of fetal hemoglobin using pharmacophore and 'PSEUDO' receptor models.
- Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex.
- Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma.
- Fetal globin stimulant therapies in the beta-hemoglobinopathies: principles and current potential.
- Effects of divalproex sodium on hemoglobin level.
- A randomized phase II trial of Arginine Butyrate with standard local therapy in refractory sickle cell leg ulcers.
- Short-term toxicity study of ST-20 (NSC-741804) by oral gavage in Sprague-Dawley rats.
- Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.
Areas of expertise and specialization
Faculty Titles & Positions
- President and Chief Medical Officer Phoenicia BioSciences, Inc. 2008 -
- Professor of Medicine, Pediatrics, and Pharmacology & Experimental Therapeutics Boston University Chobanian & Avedisian School of Medicine 1994 -
- pediatric hematologist oncologist Tufts Medical Center 2011 -
Awards
- . 1985 New Investigator Research Award
- 1993 American Society of Clinical Investigation, .
- Ignition Award 2018 Boston University School of Medicine
- Harrington Discovery Award 2020 Harrington Foundation
Professional Memberships
- American Society of Clinical Investigation
- American Academy of Inventors
- Boston University-Boston Medical Center Cancer Center
- American Society of Hematology
- American Society of Pediatric Hematology Oncology
Fellowships
- Pediatric Hematology/Oncology, Dana-Farber Cancer Institute, Boston MA 1982
- Boston Children's Hospital, Fellow:Hematology/Oncology 1979
Charities and Philanthropic Endeavors
- Foundation for Sickle Cell Research
Fellowships
- Boston Children's Hospital, Dana Farber Cancer Institute, Harvard Medical School
Articles and Publications
- > 100 publications in hematology, oncology, drug discovery
Dr. Susan P. Perrine MD, SM, MMS's reviews
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Leading Cutting-Edge Research and Clinical Excellence at Phoenicia BioSciences, Inc. and Beyond
Weston, Massachusetts – Dr. Susan P. Perrine, a distinguished figure in the field of medicine, has been at the forefront of groundbreaking research and clinical advancements in hematology, oncology, and orphan diseases. Serving as the President and Chief Medical Officer at Phoenicia BioSciences, Inc. since August 2008, Dr. Perrine has steered the company towards the discovery and development of cutting-edge therapeutics while fostering strategic industry partnerships and spearheading innovative clinical trial designs.
With an illustrious career spanning over decades, Dr. Perrine's contributions to the medical community are immeasurable. As a Professor of Medicine, Pediatrics, and Pharmacology & Experimental Therapeutics at Boston University Chobanian & Avedisian School of Medicine since March 1994, she has been instrumental in directing translational research and clinical trials aimed at developing novel therapeutics and patient care strategies for various blood diseases.
In addition to her academic role, Dr. Perrine has served as a dedicated pediatric hematologist oncologist at Tufts Medical Center since February 2011, providing specialized medical care to pediatric patients battling blood diseases. Her compassionate approach and commitment to improving patient outcomes have earned her the respect and admiration of colleagues and patients alike.
Dr. Perrine’s academic journey reflects her pursuit of excellence and commitment to advancing medical knowledge. She obtained Master of Science and Master of Public Health degrees from Harvard T.H. Chan School of Public Health before earning her Medical Degree from Tufts University School of Medicine in 1976. Her extensive training includes residencies at Tufts Medical Center and fellowships at Boston Children's Hospital/Boston Medical Center, culminating in board certifications in pediatrics and pediatric hematology-oncology.
Dr. Perrine is an esteemed member of the Boston University-Boston Medical Center Cancer Center and the Institute for Genome Sciences. Her affiliations underscore her dedication to collaboration, research excellence, and advancing the field of hematology and oncology.
Dr. Susan P. Perrine’s relentless pursuit of medical innovation and unwavering commitment to patient care continue to inspire and drive advancements in the field of hematology and oncology. Her visionary leadership and expertise position her as a trailblazer in the medical community, shaping the future of healthcare for generations to come.
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