Dr. Thomas L Rothstein M.D.
Hematologist-Oncologist | Hematology & Oncology
Boston Medical Center 650 Albany St-Ebr C Boston MA, 02118About
Dr. Thomas Rothstein is a hematologist oncologist practicing in Boston, MA. Dr. Rothstein specializes in the diagnosis, treatment and prevention of blood diseases such as anemia, hemophilia, sickle-cell disease, leukemia and lymphoma. Hematologist Oncologists are also trained in the study of cancer and its attack on other organs.
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM
Provider Details
Expert Publications
Data provided by the National Library of Medicine- BCR engagement induces Fas resistance in primary B cells in the absence of functional Bruton's tyrosine kinase.
- B cell activation leads to upregulated expression of the murine Sik-similar protein gene.
- Cutting edge commentary: two B-1 or not to be one.
- Interleukin-4-mediated protection of primary B cells from apoptosis through
- Cutting edge: CD40 engagement eliminates the need for Bruton's tyrosine kinase in B cell receptor signaling for NF-kappa B.
- NF-kappa B is required for surface Ig-induced Fas resistance in B cells.
- Cell cycle control mechanisms in B-1 and B-2 lymphoid subsets.
- Phosphatidylinositol 3-kinase-dependent mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 and NF-kappa B signaling pathways are required for B cell antigen receptor-mediated cyclin D2 induction in mature B cells.
- Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger.
- Peritoneal and splenic B-1 cells are separable by phenotypic, functional, and transcriptomic characteristics.
- Spontaneously Ig-secreting B-1 cells violate the accepted paradigm for expression of differentiation-associated transcription factors.
- B cell receptor (BCR) cross-talk: CD40 engagement enhances BCR-induced ERK activation.
- Interleukin-4 produces a breakdown of tolerance in vivo with autoantibody formation and tissue damage.
- B cell receptor (BCR) cross-talk: IL-4 creates an alternate pathway for BCR-induced ERK activation that is phosphatidylinositol 3-kinase independent.
- B cell receptor (BCR) cross-talk: CD40 engagement creates an alternate pathway for BCR signaling that activates I kappa B kinase/I kappa B alpha/NF-kappa B without the need for PI3K and phospholipase C gamma.
Dr. Thomas L Rothstein M.D.'s Practice location
Thomas Rothstein
Boston Medical Center 650 Albany St-Ebr C -Boston, MA 02118Get Direction
Boston Medical Center
650 Albany St-Ebr C 437 -Boston, MA 02118Get Direction
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Nearest Hospitals
TUFTS MEDICAL CENTERl
800 WASHINGTON STREET BOSTON MA 2111BOSTON CHILDREN'S HOSPITALl
300 LONGWOOD AVENUE BOSTON MA 2115