Dr. Alan R Leff MD
Pulmonologist | Pulmonary Disease
180 Harvester Dr Suite 110 Willowbrook IL, 60527About
Dr. Alan Leff practices Pulmonology in Willowbrook, IL. A pulmonologist is a physician who possesses specialized knowledge and skill in the diagnosis and treatment of pulmonary conditions and diseases. Dr. Leff manages patients who need life support and mechanical ventilation, and is specially trained in diseases and conditions of the chest, particularly pneumonia, asthma, tuberculosis, emphysema, and complicated chest infections.
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM- Pulmonary Disease
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2.
- Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils.
- Cytosolic phospholipase A2 activation is essential for beta 1 and beta 2 integrin-dependent adhesion of human eosinophils.
- Augmentation of eosinophil degranulation and LTC(4) secretion by integrin-mediated endothelial cell adhesion.
- Relationship of cellular transmigration and airway response after allergen challenge.
- Role of leukotrienes in bronchial hyperresponsiveness and cellular responses in airways.
- CD4+ T cell and eosinophil adhesion is mediated by specific ICAM-3 ligation and results in eosinophil activation.
- Augmentation of LTC(4) synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro.
- A surrogate method for assessment of beta(2)-integrin-dependent adhesion of human eosinophils to ICAM-1.
- Characterization of monoclonal antibodies specific for 14-kDa human group V secretory phospholipase A2 (hVPLA2).
- Involvement of protein tyrosine kinases in activation of human eosinophils by platelet-activating factor.
- Role of leukotrienes in bronchial hyperresponsiveness and cellular responses in airways.
- Mechanism of human group V phospholipase A2 (PLA2)-induced leukotriene biosynthesis in human neutrophils. A potential role of heparan sulfate binding in PLA2 internalization and degradation.
- Regulation of leukotrienes in the management of asthma: biology and clinical therapy.
- Blockade of eosinophil migration and airway hyperresponsiveness by cPLA2-inhibition.
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