Dr. Michael B Yaffe M.D.
Surgeon | Surgical Critical Care
1 Chesbrough Rd West Roxbury MA, 02132About
Dr. Michael Yaffe is a general surgeon practicing in West Roxbury, MA. Dr. Yaffe specializes in abdominal contents including the esophagus, stomach, liver, gallbladder, pancreas and often thyroid glands. General surgeons are able to deal with almost any surgical or critical care emergency, also involving the skin or soft tissue trauma. Dr. Yaffe provides quality surgical service for gravely ill or injured patients and is able to respond quickly due to knowledge of various surgical procedures.
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding.
- Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
- Signal transduction. Grabbing phosphoproteins.
- A novel pro-Arg motif recognized by WW domains.
- Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains.
- Cellular signaling in critical care--putting the pieces together.
- MAP kinase pathways activated by stress: the p38 MAPK pathway.
- 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity.
- Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.
- 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.
- Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries.
- A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase.
- The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
- TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.
- A motif-based profile scanning approach for genome-wide prediction of signaling pathways.
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