Dr. David J. Looney, MD

Expert Publications

• A disulfide-bound HIV-1 V3 loop sequence on the surface of human rhinovirus 14 induces neutralizing responses against HIV-1.
• Evolution of envelope sequences of human immunodeficiency virus type 1 in cellular reservoirs in the setting of potent antiviral therapy.
• Altered immunophenotype of dendritic cells generated from HIV infected subjects.
• Differential effects of HIV-1 protease inhibitors on dendritic cell immunophenotype and function.
• Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme.
• Lentiviral vectors pseudotyped with minimal filovirus envelopes increased gene transfer in murine lung.
• Type-specific and cross-reactive neutralizing antisera against HIV elicited by V3-peptide heptalysine octomers.
• Feline immunodeficiency virus: a concise review.
• Characterization of a mobilization-competent simian immunodeficiency virus (SIV) vector containing a ribozyme against SIV polymerase.
• Transduction of cell lines and primary cells by FIV-packaged HIV vectors.
• Small interfering RNA-induced transcriptional gene silencing in human cells.
• Efficient gene transfer to retinal pigment epithelium cells with long-term expression.
• Role of the fusogenic peptide sequence in syncytium induction and infectivity of human immunodeficiency virus type 2.
• Characterization of human immunodeficiency virus (HIV)-2 vector mobilization by HIV-1.
• Differences in the interaction of HIV-1 and HIV-2 with CD4.

Media Releases

Get to know Infectious Disease Specialist Dr. David J. Looney, who serves patients in San Diego, California.

Dr. Looney is an attending Infectious Disease physician and the HIV Lead Clinician at VA San Diego Healthcare System (VASDHS). He also serves as Associate Professor at UCSD and Co-Director Director of the University of California San Diego CFAR Genomics and Sequencing Core, supporting multiple HIV-cure related projects by providing via cutting-edge, quantitative integration assays using next-generation sequencing (NGS) capable of characterizing clonal (non-replicative) expansion of HIV and advanced viral quantitation for cure studies using droplet-digital PCR.

He received his Bachelor of Science degree in Physics from the Washington University in St. Louis, and received his Doctor of Medicine degree Cum Laude from the University of Missouri School of Medicine in 1979. He completed his internship and residency in internal medicine at the Letterman Army Medical Center in 1982, and his fellowship in infectious disease at the Brooke Army Medical Center in 1986.  He also completed training in Tropical Medicine at the Walter Reed Army Institute of Research, and performed  postdoctoral training at National Robert allo’s Laboratory of Tumor Cell Biology at the NIH from 1986-1989.

Dr. Looney is a Fellow of the American College of Physicians (FACP), and is board-certified in Infectious Disease and Internal Medicine by the American Board of Internal Medicine (ABIM). Other roles include Hospital Epidemiologist at the VA San Diego Healthcare Center where is he also serves as Chair of the Infection Prevention and Control Committee, Co-Chair of the VASDHS Removable Medical Equipment Committee, and Co-Chair of the VASDHS Antimicrobial Stewardship Committee.

Infectious disease is a medical specialty dealing with the prevention, the diagnosis, and the treatment of all infections. An infectious disease specialist’s practice also consists of managing nosocomial (hospital-acquired) infections.

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