Dr. Jesse E. Otero, MD

Areas of expertise and specialization

Faculty Titles & Positions

• Director of Hip and Knee Research OrthoCarolina Research Institute 2019 - Present
• Clinical Associate Professor Wake Forest School of Medicine 2020 - Present
• Research Assistant Palo Alto Veterans Affairs Hospital 2002 -
• Doctoral Candidate Medical Scientist Training Program – Washington University in St. Louis School of Medicine – Laboratory of Yousef Abu-Amer 2006 - 2009
• Orthopaedic Surgery Resident University of Iowa Hospitals and Clinics 2011 - 2016
• Orthopaedic Surgeon and Clinical Fellow Adult Hip and Knee Reconstruction OrthoCarolina, Charlotte 2016 - 2017
• Assistant Professor Orthopaedic Surgery in Adult Hip and Knee Reconstruction – Department of Orthopaedic Surgery - University of Iowa Hospitals and Clinics 2017 - 2019
• Associate Professor OrthoCarolina Hip and Knee Center, Atrium Health Musculoskeletal Institute 2019 - Present
• Teaching Assistant Washington University Medical School Curriculum 2006 -

Awards

• • MD/PhD Candidate Year Medical Scientist Training Program Washington University 2005 – 2011 
• • Honors Distinction - Bachelors in Biological Sciences 2004 Stanford University 
• • Best Paper 2024 – One versus Two Stage Treatment for Prosthetic Joint Infection: A Prospective, Randomized Clinical Trial 2024 American Academy of Orthopaedic Surgeons Annual Meeting 
• • AΩA Medical Honor Society 2010  
• • The Dr. John Esben Kirk Award for Scholastic Achievement in Medical School 2011  
• • Palo Alto Institute for Research and Education Grant 2002 – 2004 Year  
• • Stanford Undergraduate Research Organization Fellowship (HHMI) 2003  
• • American Society for Bone and Mineral Research Young Investigator Award 2009  
• • American Society for Bone and Mineral Research Young Investigator Travel Grant 2007  
• • Top Paper Award – Hip – One versus Two Stage Treatment for Prosthetic Joint Infection: A Prospective, Randomized Clinical Trial 2024 American Academy of Orthopaedic Surgeons Annual Meeting 
• • Mid-America Orthopaedic Association Education Grant for Senior Residents 2016  
• • Best Paper Award – One versus Two Stage Treatment for Prosthetic Joint Infection: A Prospective, Randomized Clinical Trial 2024 American Association of Hip and Knee Surgeons. Annual Meeting 
• • Selected participant AAOS ORS OREF Clinician Scholar Career Development Program 2013  

Professional Memberships

• Reviewer - Journal of Arthroplasty  
• Musculoskeletal Infection Society Member  
• American Association of Hip and Knee Surgeons  
• American Academy of Orthopaedic Surgeons  
• Reviewer – Journal of Bone and Joint Infection  
• AAHKS Research Committee – 2017- Presen  
• American Joint Replacement Registry Research Publications Committee - 2020 - present  
• Reviewer – Journal of Bone and Joint Surgery  

Fellowships

• OrthoCarolina Adult Hip and Knee Reconstruction   2017

Charities and Philanthropic Endeavors

• Charlotte Area Habitat for Humanity
• Care Ring

Fellowships

• OrthoCarolina Adult Hip and Knee Reconstruction

Articles and Publications

• 1.Naufal ER, Wouthuyzen-Bakker M, Soriano A, Young SW, Higuera-Rueda CA, Otero JE, Fillingham YA, Fehring TK, Springer BD, Shadbolt C, Tay ML, Aboltins C, Stevens J, Darby J, Poy Lorenzo YS, Choong PFM, Dowsey MM, Babazadeh S. The Orthopaedic Device Infection Network: Building an Evidence Base for the Treatment of Periprosthetic Joint Infection Through International Collaboration. J Arthroplasty. 2024 Jun;39(6):1391-1393. PMID: 38490566.2.Otero JE, Dombrowski ME, Brown TS, Courtney PM, Kamath AF, Nandi S, Fehring KA. What's New in Musculoskeletal Infection. J Bone Joint Surg Am. 2024 Jul 17;106(14):1249-1255. PMID: 38781349.3.Dombrowsky A, Jolissaint J, Otero JE. Pasteurella multocida From a Cat Scratch as a Cause of Recurrent Prosthetic Joint Infection After Previously Successful Single-Stage Exchange Arthroplasty. Arthroplast Today. 2024 Apr 23;27:101351.. PMID: 386900924.Behery O, Shing E, Yu Z, Springer BD, Fehring TK, Beaver WB, Otero JE. Radiographic Cone Zone Classification of Metaphyseal Cone Fixation in Revision Total Knee Arthroplasty. Arthroplasty Today. 2024 Jan 22:25:101271. PMID: 383042465.Metcalf R, Dombrowski ME, Odum SM, Otero JE. The influence of Patient Sex on Outcomes Following One-Stage and Two-Stage Revision for Periprosthetic Joint Infection in Total Joint Arthroplasty. Antibiotics (Basel). 2023 Aug 31;12(9):1392. doi: 10.3390/antibiotics12091392 PMID: 377606886.Otero JE, Heckmann ND, Jaffri H, Mullen KJ, Odum SM, Lieberman JR, Springer BD. Dual Mobility Articulation in Revision Total Hip Arthroplasty: An American Joint Replacement Registry Analysis of Patients Aged 65 Years and Older. J Arthroplasty. 2023 Jul;38(7 Suppl 2):S376-S380. doi: 10.1016/j.arth.2023.05.023 Epub 2023 May 24. PMID: 372302277.Herndon CL, Rowe T, Metcalf R, Odum S, Fehring TK, Springer BD, Otero JE. Treatment Outcomes of Fungal Periprosthetic Joint Infection. J Arthroplasty. 2023 Nov;38(11):2436-2440.e1. doi: 10.1016/j.arth.2023.05.009 Epub 2023 May 12. PMID: 371790248.Fehring TK, Otero JE, Curtin BM, Fehring KA, Metcalf R, Rowe TM, Springer BD. Does Treatment at a Specialized Prosthetic Joint Infection Center Improve the Rate of Reimplantation. J Arthroplasty. 2023 Jun;38(6S):S314-S317. doi: 10.1016/j.arth.2023.03.082 Epub 2023 Mar 31. PMID: 370049689.Green CC, Valenzuela MM, Odum SM, Rowe TM, Springer BD, Fehring TK, Otero JE. Hypoalbuminemia Predicts Failure of Two-Stage Exchange for Chronic Periprosthetic Joint Infection of the Hip and Knee. J Arthroplasty. 2023 Jul;38(7):1363-1368. doi: 10.1016/j.arth.2023.01.012 Epub 2023 Jan 21. PMID: 3669351510.Adrados M, Curtin BM, Springer BD, Otero JE, Fehring TK, Fehring KA. High Rate of Intramedullary Culture Positivity in Total Knee Arthroplasty Resection for Prosthetic Joint Infection. J Arthroplasty. 2023 Jul;38(7):1369-1372. doi: 10.1016/j.arth.2023.01.017 Epub 2023 Jan 23. PMID: 3670243811.Adrados M, Valenzuela MM, Springer BD, Odum SM, Fehring TK, Otero JE. Has the time come for regional periprosthetic joint infection centers in the United States? A first-year experience. J Bone Jt Infect. 2022 Mar 1;7(1):51-53. doi: 10.5194/jbji-7-51-2022 eCollection 2022. PMID: 3528032312.Otero JE, Brown TS, Courtney PM, Kamath AF, Nandi S, Fehring KA. Whats New in Musculoskeletal Infection. J Bone Joint Surg Am. 2022 Jul 20;104(14):1228-1235. doi: 10.2106/JBJS.22.00183 Epub 2022 May 25 .PMID: 3570008513.Valenzuela ML, Odum SM, Griffin WL, Springer BD, Fehring TK, Otero JE. High-Dose Antibiotic Cement Spacers Independently Increase the Risk of Acute Kidney Injury in Revision for Periprosthetic Joint Infection: A Prospective Randomized Controlled Clinical Trial. J Arthroplasty. 2022 Jun;37(6S):S321-S326. doi: 10.1016/j.arth.2022.01.060 Epub 2022 Feb 21. PMID: 35210153 Clinical Trial.14.Behery O, Shing E, Yu Z, Springer BD, Fehring TK, Otero JE. Survivorship and Radiographic Evaluation of Metaphyseal Cones with Short Cemented Stems in Revision Total Knee Arthroplasty. J Arthroplasty. 2022 Feb;37(2):330-335. doi: 10.1016/j.arth.2021.10.027 Epub 2021 Nov 3. PMID: 3474287315.Johnson NR, Otero JE. Prevention of Periprosthetic Joint Infection of the Hip and Knee: Modern Techniques and Strategies. J Surg Orthop Adv. 2021 Winter;30(4):202-206. PMID: 3510818216.Cox ZC, Green CC, Otero JE, Mason JB, Martin JR. Varus Collapse in Total Knee Arthroplasty: Does Fixation or Bone Fail First? J Arthroplasty. 2022 Jan;37(1):162-167. doi: 10.1016/j.arth.2021.09.012 Epub 2021 Sep 28. PMID: 3459235417.Acua AJ, Do MT, Samuel LT, Grits D, Otero JE, Kamath AF. Periprosthetic Joint Infection Rates Across Primary Total Hip Arthroplasty Surgical Approaches: A Systematic Review and Meta-Analysis of 653,633 Procedures. Arch Orthop Trauma Surg. 2022 Oct;142(10):2965-2977. doi: 10.1007/s00402-021-04186-3 Epub 2021 Sep 30. PMID: 34595547 Review.18.Li KK, Cuadra M, Scarola G, Odum S, Otero J, Griffin W, Springer BD. Complications in the Treatment of Periprosthetic Joint Infection of the Hip: When Do Then Occur? J Bone Jt Infect. 2021 Jul 29;6(7):295-303. doi: 10.5194/jbji-6-295-2021 eCollection 2021. PMID: 3437762919.Kildow BJ, Patel SP, Otero JE, Fehring KA, Curtin BM, Springer BD, Fehring TK. Results of debridement, antibiotics, and implant retention for periprosthetic knee joint infection supplemented with the use of intraosseous antibiotics. Bone Joint J. 2021 Jun;103-B(6 Supple A):185-190. doi: 10.1302/0301-620X.103B6.BJJ-2020-2278.R1 PMID: 3405328020.Johnson NR, Odum SM, Lastra J, Fehring KA, Springer BD, Otero JE. Pain and Anxiety Due to the COVID-19 Pandemic: A Survey of Patients with Delayed Elective Hip and Knee Arthroplasty. Arthroplast Today. 2021 Aug;10:27-34. doi: 10.1016/j.artd.2021.05.013 Epub 2021 May 28. PMID: 3409539721.Statz JM, Odum SM, Johnson NR, Otero JE. Failure to Medically Optimize Prior to THA. Which Modifiable Risk Factor is the Most Dangerous? Arthroplast Today. 2021 Jul 5;10:18-23. doi: 10.1016/j.artd.2021.05.021 eCollection 2021 Aug. PMID: 3427790622. Li KK, Cuadra M, Scarola G, Odum S, Otero JE, Griffin WL, Springer BD. Complications in the Treatment of Periprosthetic Joint Infection of the Hip: When Do They Occur? J Bone Jt Infect. 2021 Jul 29;6(7):295-303. doi: 10.5194/jbji-6-295-2021 eCollection 2021. PMID: 3437762923.Johnson NR, Statz JM, Odum SM, Otero JE. Failure to optimize prior to total knee arthroplasty: Which modifiable risk factor is the most dangerous? J Arthroplasty. 2021 Jul;36(7):2452-2457. doi: 10.1016/j.arth.2021.02.061 Epub 2021 Feb 27. PMID: 3375292524.Martin JR, Otero JE, Mason JB, Fehring TK. Where is the Weak Link of Fixation in Contemporary Cemented Total Knee Replacements? J Arthroplasty. 2021 Jul;36(7):2497-2501. doi: 10.1016/j.arth.2021.02.029 Epub 2021 Feb 12. PMID: 3367681325.Wynn MS, Carender CN, Solsrud E, Clark CR, Otero JE, Brown TS. Radiographic Evaluation of Proximal Femoral Nutrient Arteries After Total Hip Arthroplasty with a Short Femoral Stem. J Arthroplasty. 2021 Jun;36(6):2076-2079. doi: 10.1016/j.arth.2021.02.003 Epub 2021 Feb 10. PMID: 3367416226.Carender CN, DeMik DE, Otero JE, Noiseux NO, Brown TS, Bedard NA. What is the Clinical Utility of Synovial Alpha-Defensin Testing of Antibiotic Spacers Prior to Reimplantation? J Arthroplasty. 2021 Jun;36(6):2150-2157. doi: 10.1016/j.arth.2021.02.001 Epub 2021 Feb 5. PMID: 3364884127.Muffly SA, An Q, Bedard NA, Brown TS, Otero JE. Early Emergency Department Visits Following Primary Hip and Knee Arthroplasty. J Arthroplasty. 2021 Jun;36(6):1915-1920. doi: 10.1016/j.arth.2021.01.058 Epub 2021 Jan 28. PMID: 3359711228.Trinh JQ, Carender CN, An Q, Noiseux NO, Otero JE, Brown TS. Resilience and Depression Influence Clinical Outcomes Following Primary Total Joint Arthroplasty. J Arthroplasty. 2021 May;36(5):1520-1526. doi: 10.1016/j.arth.2020.11.032 Epub 2020 Nov 25. PMID: 3333464029.Phruetthiphat O, Otero JE, Zampogna B, Vasta S, Gao Y, Callaghan JJ. Predictors of readmission following primary total hip and total knee arthroplasty. J Orthop Surg (Hong Kong). 2020 Sep-Dec;28(3):2309499020959160. doi: 10.1177/2309499020959160 PMID: 3302114530.Carender CC, Wynn MS, Otero JE, Miller BJ, Brown TS. Nonoperative treatment of a pathologic proximal tibia fracture in the setting of previous total knee arthroplasty. A case report. JBJS Case Connect. 2020 Apr-Jun;10(2):e0517. doi: 10.2106/JBJS.CC.19.00517 PMID: 3264912331.Arra M, Swarnkar G, Ke K, Otero JE, Ying Jun Duan X, Maruyama T, Rai MF, OKeefe RJ, Mbalaviele G, Shen J, Abu-Amer Y. LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis. Nat Commun. 2020 Jul 9;11(1):3427. doi: 10.1038/s41467-020-17242-0 PMID: 3264717132.Parvizi J, Otero JE, et al. Resuming elective orthopaedic surgery during the COVID-19 pandemic: guidelines developed by the International Consensus Group (ICM). J Bone Joint Surg Am. 2020 Jul 15;102(14):1205-1212. doi: 10.2106/JBJS.20.00844 PMID: 3267566233.Fehring TK, Fehring KA, Hewlett A, Higuera CA, Otero JE, Tande A. Whats New in Musculoskeletal Infection. J Bone Joint Surg Am. 2020 Jul 15;102(14):1222-1229. doi: 10.2106/JBJS.20.00363 PMID: 3267567134.Carander C, Meyer M, Otero J, Brown T. The Prevalence of Abnormal Spinopelvic Relationships in Patients Presenting for Primary Total Hip Arthroplasty. Arthroplast Today. 2020 Jun 16;6(3):381-385. doi: 10.1016/j.artd.2020.05.010 eCollection 2020 Sep. PMID: 3257748235.Barton C, Wang D, An Q, Brown T, Callaghan J, Otero J. Two-stage exchange arthroplasty for periprosthetic joint infection following total hip or knee arthroplasty is associated with high attrition rate and mortality. Arthroplasty. 2020 May;35(5):1384-1389. doi: 10.1016/j.arth.2019.12.005 Epub 2019 Dec 13. PMID: 3190261736.Compton J, Owens J, Otero J, Noiseux N, Brown T. Extramedullary Guide Alignment is not Affected by Obesity in Primary Total Knee Arthroplasty. J Knee Surg. 2021 Aug;34(10):1076-1079. doi: 10.1055/s-0040-1701438 Epub 2020 Feb 4. PMID: 3201827737.Otero JE, Martin JR, Rowe T, Odum S, Mason JB. Radiographic and Clinical Outcomes of Modular Tapered Fluted Stems for Femoral Revision for Paprosky III and IV Femoral Defects or Vancouver B2 and B3 Femoral Fractures. J Arthroplasty. 2020 Apr;35(4):1069-1073. doi: 10.1016/j.arth.2019.11.039 Epub 2019 Nov 30. PMID: 3187058238.Kesler KK, Brown TS, Martin JR, Springer BD, Otero JE. (2019). Risk Factors for Blood Transfusion after Primary Total Hip Arthroplasty. Reconstructive Review, 9(1). doi: 10.15438/rr.9.1.22639.Fehring TK, Fehring KA, Hewlett A, Higuera CA, Otero JE, Tande A. Whats New in Musculoskeletal Infection. J Bone Joint Surg Am. 2019 Jul 17;101(14):1237-1244. doi: 10.2106/JBJS.19.00403 PMID: 3131880240.Holte AJ, Carender CN, Noiseux NO, Otero JE, Brown TS. Restrictive Opioid Prescribing Protocols Following Total Hip Arthroplasty and Total Knee Arthroplasty Are Safe and Effective. J Arthroplasty. 2019 Jul;34(7S):S135-S139. doi: 10.1016/j.arth.2019.02.022 Epub 2019 Feb 20. PMID: 3089039041.Foreman CW, Callaghan JJ, Brown TS, Elkins JM, Otero JE. Total Joint Arthroplasty in the Morbidly Obese How Body Mass Index 40 Influences Patient Retention, Treatment Decisions, and Treatment Outcomes. J Arthroplasty. 2020 Jan;35(1):39-44. doi: 10.1016/j.arth.2019.08.019 Epub 2019 Aug 17. PMID: 3153046042.Elkins JM, Kates S, Lange J, Lange J, Lichstein P, Otero J, Soriano A, Wagner C, Wouthuyzen-Bakker M. General Assembly, Diagnosis, Definitions: Proceedings of International Consensus on Orthopedic Infections. J Arthroplasty. 2019 Feb;34(2S):S181-S185. doi: 10.1016/j.arth.2018.09.069 Epub 2018 Oct 19. PMID: 3034855843.Yanik JM, Bedard NA, Hanley JM, Otero JE, Callaghan JJ, Marsh JL. Rapid Recovery Total Joint Arthroplasty is Safe, Efficient, and Cost-Effective in the Veterans Administration Setting. J Arthroplasty. 2018 Oct;33(10):3138-3142. doi: 10.1016/j.arth.2018.07.004 Epub 2018 Jul 11. PMID: 3007746844.Martin JR, Otero J, Beaver W, Springer B, & Griffin W. (2018). Is Utilizing a Modular Stemmed Tibial Component in Obese Patients Undergoing Primary Total Knee Replacement Cost-Effective? Reconstructive Review, 8(2). https://doi.org/10.15438/rr.8.2.21545.Otero JE, Fehring KA, Martin JR, Odum SM, Fehring TK. Variability of Pelvic Orientation in the Lateral Decubitus Position: Are External Alignment Guides Trustworthy? J Arthroplasty. 2018 Nov;33(11):3496-3501. doi: 10.1016/j.arth.2018.07.021 Epub 2018 Jul 31. PMID: 3015015346.Bedard NA, Pugely AJ, McHugh M, Lux N, Otero JE, Bozic KJ, Gao Y, Callaghan JJ. Analysis of Outcomes after Total Knee Arthroplasty: Do all Databases Produce Similar Findings? Clin Orthop Relat Res. 2018 Jan;476(1):52-63. doi: 10.1007/s11999.0000000000000011 PMID: 2952961647.Owens JM, Callaghan JJ, Duchman KR, Bedard NA, Otero JE. Short-term Morbidity and Readmissions Increase With Skilled Nursing Facility Discharge After Total Joint Arthroplasty in a Medicare-Eligible and Skilled Nursing Facility-Eligible Patient Cohort. J Arthroplasty. 2018 May;33(5):1343-1347. doi: 10.1016/j.arth.2018.01.002 Epub 2018 Jan 11. PMID: 2942988148.Fehring T, Fehring K, Anderson L, Otero J, Springer B. Catastrophic Varus Collapse of the Tibia in Obese Total Knee Arthroplasty.J Arthroplasty. 2017 May;32(5):1625-1629. doi: 10.1016/j.arth.2016.12.001 Epub 2017 Jan 30. PMID: 2820220749.Gholson JJ, Duchman KR, Otero JE, Pugely AJ, Gao Y, Callaghan JJ. Computer Navigated Total Knee Arthroplasty: Rates of Adoption and Early Complications..J Arthroplasty. 2017 Jul;32(7):2113-2119. doi: 10.1016/j.arth.2017.01.034 Epub 2017 Jan 30. PMID: 2836631050.Gholson JJ, Noiseux NO, Otero JE, Gao Y, Shah AS. Patient Factors Systematically Influence Hospital Length of Stay in Common Orthopaedic Procedures, Iowa Orthop J. 2017;37:233-237. PMID: 2885236351.Otero JE, Graves CM, Gao Y, Olson TS, Dickinson CC, Chalus RJ, Vittetoe DA, Goetz DD, Callaghan. Patient-reported Allergies Predict Worse Outcomes after Hip and Knee Replacement: Results from a Prospective Cohort Study..J Arthroplasty. 2016 Dec;31(12):2746-2749. doi: 10.1016/j.arth.2016.07.040 Epub 2016 Aug 10. PMID: 2760030252.Otero JE, Gholson JJ, Pugely AJ, Gao Y, Bedard NA, Callaghan JJ Length of hospitalization after joint arthroplasty: Does early discharge affect complications and readmission rates? J Arthroplasty. 2016 Dec;31(12):2714-2725. doi: 10.1016/j.arth.2016.07.026 Epub 2016 Aug 9. PMID: 2760030153.Metcalf RW, Willey MC, Petersen EB, Watson NA, Fredericks DC, Otero JE. Aminobisphosphonate Therapy Enhances Bone Healing in an Osteoporotic Mammalian Fracture Model. Accepted American Journal of Orthopaedics 2018 *did not publish. Publication went out of business*54.Otero JE, Graves CM, Bollier MJ. Injuries in Collegiate Wrestlers at an Elite Division I NCAA Wrestling Program: An Epidemiological Study. Iowa Orthop J. 2017;37:65-70. PMID: 2885233755.Otero JE, Westerlind BO, Tantavisut S, Karam MD, Phisitkul P, Akoh CC, Gao Y, Marsh JL. There is poor reliability of Bhler's angle and the crucial angle of Gissane in assessing displaced intra-articular calcaneal fractures. Foot Ankle Surg. 2015 Dec;21(4):277-81. doi: 10.1016/j.fas.2015.03.001 Epub 2015 Mar 10. PMID: 2656473156.Akoh CC, Schick C, Otero J, Karam M. Fat embolism syndrome after femur fracture fixation: a case report. Iowa Orthop J. 2014;34:55-62. PMID: 2532846057.Otero JE, Stevens JW, Malandra AE, Fredericks DC, Odgren PR, Buckwalter JA, Morcuende J. Osteoclasts inhibition impairs chondrosarcoma growth and bone destruction. J Orthop Res. 2014 Dec;32(12):1562-71. doi: 10.1002/jor.22714 Epub 2014 Aug 13. PMID: 2512533658.Graves CM, Otero JE, Gao Y, Goetz DD, Willenborg MD, Callaghan JJ. Patient Reported Allergies Are a Risk Factor for Poor Outcomes in Total Hip and Knee Arthroplasty. J Arthroplasty. 2014 Sep;29(9 Suppl):147-9. doi: 10.1016/j.arth.2014.02.040 Epub 2014 Jun 6. PMID: 2503488159.Otero JE, Graves CM, TeKippe A, Buckwalter JA, Miller BJ. Factors Affecting Outcomes in Patients Treated Surgically for Upper Extremity Tumors and Tumor-like Lesions. Iowa Orthop J. 2013;33:119-29. PMID: 2402747160.Cassel SL, Janczy JR, Bing X, Wilson SP, Olivier AK, Otero JE, Iwakura Y, Shayakhmetov DM, Bassuk AG, Abu-Amer Y, Brogden KA, Burns TL, Sutterwala FS, Ferguson PJ. Inflammasome-independent IL-1 mediates autoinflammatory disease in Pstpip2-deficient mice. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1072-7. doi: 10.1073/pnas.1318685111 Epub 2014 Jan 6. PMID: 2439580261.Zhang YH, Otero JE, Abu-Amer Y. Ubiquitin-Like Domain of IKK Regulates Osteoclastogenesis and Osteolysis. Calcif Tissue Int. 2013 Jul;93(1):78-85. doi: 10.1007/s00223-013-9735-5 Epub 2013 May 18. PMID: 2368624662.Otero JE, Chen T, Zhang K, Abu-Amer Y. Constitutively Active canonical NF-B induces severe bone loss in mice. PLoS One. 2012;7(6):e38694. doi: 10.1371/journal.pone.0038694 Epub 2012 Jun 7. PMID: 2268559963.Morcuende J, Stevens J, Sheetz T, Bonaldo MdF, Casavant T, Otero JE, Soares MB. Swarm Rat Chondrosarcoma Cells as an in vivo Model: Lung colonization and Effects of Tissue Environment on Tumor Growth. Iowa Orthop J. 2012;32:46-53. PMID: 2357692164.Otero JE, Gottesman GS, McAlister WH, Mumm S, Madson KL, Whyte MP. Severe Skeletal Toxicity from Protracted Etidronate Therapy for Generalized Arterial Calcification of Infancy. February 2013; 28(2): 419-430. J Bone Miner Res. 2013 Feb;28(2):419-30. doi: 10.1002/jbmr.1752 PMID: 2297271665.Yang JS, Otero JE, McAndrew CM, Ricci WM, Gardner MJ. Can tibial nonunion be predicted at 3 months after intramedullary nailing? J Orthop Trauma. 2013 Nov;27(11):599-603. doi: 10.1097/BOT.0b013e31828f5821 PMID: 2348191966.Otero JE, Dai S, Alhawagri M, Darwech I, Abu-Amer Y. IKK Activation is Sufficient for RANK-Independent Osteoclast Differentiation and Osteolysis. J Bone Miner Res. 2010 Jun;25(6):1282-94. doi: 10.1002/jbmr.4 PMID: 2020095567.Otero J*, Darwech I*, Alhawagri M, Abu-Amer Y. Tyrosine Phosphorylation of IB Kinase-beta (IKK) activation and function in osteoclastogenesis. *Co-First Authors J Biol Chem. 2010 Aug 13;285(33):25522-30. doi: 10.1074/jbc.M110.121533 Epub 2010 Jun 9. PMID: 2053458568.Otero JE, Dai S, Foglia D, Alhawagri M, Vacher J, Pasparakis M, Abu-Amer Y. Defective osteoclastogenesis by IKKbeta -null precursors is a result of RANKL-induced JNK-dependent apoptosis and impaired differentiation. J Biol Chem. 2008 Sep 5;283(36):24546-53. doi: 10.1074/jbc.M800434200 Epub 2008 Jun 19. PMID: 1856757969.Yamanaka Y, Abu-Amer W, Foglia D, Otero J,Clohisy JC, Abu-Amer Y. NFAT2 is an essential mediator of orthopedic particle-induced osteoclastogenesis. J Orthop Res. 2008 Dec;26(12):1577-84. doi: 10.1002/jor.20714 PMID: 1865513970.Darwech I, Otero J, Alhawagri M, Dai S, Abu-Amer Y. Impediment of NEMO oligomerization inhibits osteoclastogenesis and osteolysis. J Cell Biochem. 2009 Dec 15;108(6):1337-45. doi: 10.1002/jcb.22364 PMID: 1983070371. Abu-Amer, Y., Darwech, I. and Otero, J. (2007). Osteoporosis and Osteopetrosis. In eLS, (Ed.). https://doi.org/10.1002/9780470015902.a000601772.Abu-Amer Y, Darwech I, Otero J. Role of the NF-kappaB axis in immune modulation of osteoclasts and bone loss. Autoimmunity. 2008 Apr;41(3):204-11. doi: 10.1080/08916930701694543 PMID: 1836583373.Ulaner GA, Huang HY, Otero J, Zhao Z, Ben-Porat L, Satagopan JM, Gorlick R, Meyers P, Healey JH, Huvos AG, Hoffman AR, Ladanyi M. Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma. Cancer Res. 2003 Apr 15;63(8):1759-63. PMID: 1270255874.Ulaner GA, Hoffman AR, Otero J, Huang HY, Zhao Z, Mazumdar M, Gorlick R, Meyers P, Healey JH, Ladanyi M. Divergent patterns of telomere maintenance mechanisms among human sarcomas: sharply contrasting prevalence of the alternative lengthening of telomeres mechanism in Ewing's sarcomas and osteosarcomas. Genes Chromosomes Cancer. 2004 Oct;41(2):155-62. doi: 10.1002/gcc.20074 PMID: 1528702875.Padmanabhan P, Otero J, Ray P, Paulmurugan R, Hoffman AR, Gambhir SS, Biswal S, Ulaner GA. Visualization of telomerase reverse transcriptase (hTERT) promoter activity using a trimodality fusion reporter construct. J Nucl Med. 2006 Feb;47(2):270-7. PMID: 16455633

What do you attribute your success to?

• I attribute my success in my career to three key factors: a relentless drive to help patients who are suffering from pain to restore their mobility, phenomenal mentors who have shown me the way to take care of patients, and finally, an excellent education.

Areas of research

• Outcomes in total joint arthroplasty, prosthetic joint infection

Teaching and speaking

• Attending Atrium Orthopedic residencyAttending OrthoCarolina Adult Hip and Knee Reconstruction Fellowship

Favorite professional publications

• Journal of Arthroplasty

Areas of research

Joint Replcement Outcomes

Periprosthetic Joint Infection

Dr. Jesse E. Otero, MD's Practice location