Dr. Carlo L. Mainardi, MD, MBA, FACP, FACR

Expert Publications

• Characterization of type V collagenase (gelatinase) in synovial fluid of patients with inflammatory arthritis.
• Differentiation of PC12 cells with nerve growth factor is associated with induction of transin synthesis and release.
• Immunolocalization of metalloproteinases in collagen autoimmune arthritis.
• Induction of stromelysin synthesis is associated with PC12 cell differentiation stimulated by nerve growth factor.
• Inflammatory phagocytes and connective tissue degrading metalloproteinases.
• Cellular control of collagen breakdown in rheumatoid arthritis.
• Cellular control of collagen breakdown in rheumatoid arthritis.
• Collagenase immunolocalization in cultures of rheumatoid synovial cells.
• Collagenase immunolocalization in cultures of rheumatoid synovial cells.
• Activation in vitro of rheumatoid synovial collagenase from cell cultures.
• Activation in vitro of rheumatoid synovial collagenase from cell cultures.
• Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.
• Secretion and glycosylation of rabbit macrophage type V collagenase.
• Inhibitor of human collagenase from cultures of human tendon.
• Inhibitor of human collagenase from cultures of human tendon.

Media Releases

Leaving Behind a Legacy of Clinical Excellence in Hendersonville, North Carolina

After nearly five decades of providing exceptional care in the field of rheumatology, Dr. Carlo Mainardi, MD, retired from practice in 2023. He leaves behind a legacy of dedication, expertise, and compassion, having positively impacted the lives of countless patients throughout his esteemed career.

After studying biology at Franklin and Marshall College, Dr. Mainardi went on to attend medical school in Italy for three years before transferring to Rutgers New Jersey Medical School where he graduated with his Medical Degree in 1972. He went on to complete both his residency and fellowship at the Dartmouth-Hitchcock Medical Center in Lebanon, New Hampshire where he spent additional time on the faculty as an assistant professor. 

Over the years, Dr. Mainardi honed his skills and expertise through various prestigious roles, culminating in his appointment as the Chief Medical Officer at AdventHealth Hendersonville in North Carolina in 2012. During his tenure, he established the AdventHealth Rheumatology Department, bringing specialized care to the community.

In 2018, Dr. Mainardi made the decision to transition away from his administrative duties to focus solely on direct patient care, a testament to his unwavering commitment to his patients’ well-being. His dedication and expertise in the field of rheumatology have left an indelible mark on the healthcare landscape of North Carolina.

Throughout his illustrious career, Dr. Mainardi distinguished himself as a leader in rheumatology, earning board certifications in both internal medicine and rheumatology from the American Board of Internal Medicine. He was also recognized as a Fellow of the American College of Physicians (FACP) and a Fellow of the American College of Rheumatology (FACR), underscoring his commitment to excellence and continuous learning.

Dr. Mainardi’s impact extended beyond his clinical practice, as he actively contributed to the advancement of rheumatology through research, education, and mentorship. His dedication to the field of rheumatology has earned him the respect and admiration of colleagues and patients alike, culminating in numerous accolades such as Castle Connolly's Top Physicians, Consumers Research Council’s America’s Top Physicians, and New Jersey Monthly’s Top Physician.

As Dr. Carlo Mainardi embarks on this new chapter in his life, he looks forward to spending more time pursuing his passions outside of medicine. In his free time, he enjoys playing golf, indulging in a good book, and exploring the world through travel, reflecting his lifelong commitment to living a balanced and fulfilling life.

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