Dr. David Chun kang Huang MD
Internist
275 Victoria St Suite# 2b Costa Mesa CA, 92627About
Dr. David Huang is an internist practicing in Costa Mesa, CA. Dr. Huang specializes in the medical treatment of adults. Internists can act as a primary physician or a consultant to a primary physician. They manage both common and rare diseases. Dr. Huang provides comprehensive care and manages treatment with surgeons as well. Internists establish long-term relationships with their patients and incorporate disease prevention and mental health care into their practice.
Education and Training
Taipei Med University 1979
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Direct addition of BimL to mitochondria does not lead to cytochrome c release.
- Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs.
- The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity.
- Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity.
- The Bcl-2-regulated apoptotic pathway.
- Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.
- The Bcl-2 family: roles in cell survival and oncogenesis.
- Protein hijacking: key proteins held captive against their will.
- Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.
- Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.
- Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.
- FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells.
- Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance.
- How the Bcl-2 family of proteins interact to regulate apoptosis.
- The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
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