Dr. Constantine D. Mavroudis, MD, MSc, MTR

Expert Publications

• Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation.
• Impact of noncardiac congenital and genetic abnormalities on outcomes in hypoplastic left heart syndrome.
• Cerebral protection for aortic arch surgery: hybrid approach.
• Shepherd hook anomaly of ductus arteriosus with sudden intrapartum fetal demise: two case reports.
• Native pulmonary valve restoration after remote tetralogy of fallot repair: how to do it.
• Hybrid repair of a ruptured right-sided aortic arch with an aberrant left subclavian artery arising from a diverticulum of Kommerell: a case report.
• Pulmonary valve preservation and restoration strategies for repair of tetralogy of Fallot.

Media Releases

Get to know Cardiothoracic Surgeon Dr. Constantine D. Mavroudis, who serves patients in Philadelphia, Pennsylvania.

Following in his father’s footsteps, Dr. Mavroudis is a pediatric congenital heart surgeon. He works within the Division of Cardiothoracic Surgery at Children’s Hospital of Philadelphia (CHOP).

Some of the Departments and programs that he is affiliated with include: Cardiac Center, Cardiovascular Connective Tissue Disorders Clinic, Pediatric Lung Transplant Program, Heart Failure and Transplant Program, Philadelphia Adult Congenital Heart Center, and Pulmonary Vein Stenosis Program.

“Kids are pretty amazing. Even when they have been hospitalized, they don’t always seem to know they’re sick. They still find a way to be kids. In addition to the endless range of conditions and anatomical complexity inherent to treating children, that resilience and innocence drives me to make sure my patients can focus on just being kids. I remember rounding with my dad and seeing sick kids in the cardiac ICU who were otherwise just like me. Looking back, that had a profound impact. Congenital heart disease affects 1% of the population and can happen to anybody. I want my patients to get back to being kids and enjoying life. While my patients have a profound impact on me, I want them to live their lives without thinking about surgery and without thinking about their disease” expressed Dr. Mavroudis. 

In affiliation with Penn Health, he has privileges to treat patients at Penn Heart and Vascular Center, the Ruth and Raymond Perelman Center for Advanced Medicine, the Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, and Pennsylvania Hospital.

A graduate of Williams College, where he majored in philosophy, Dr. Mavroudis went on to receive his medical degree from Loyola University Chicago’s Stritch School of Medicine. He then performed his residency in cardiothoracic surgery at the Hospital of the University of Pennsylvania, his postdoctoral research fellowship within the Department of Cardiothoracic Surgery at Children’s Hospital of Philadelphia, and his fellowship in congenital cardiothoracic surgery at the Children’s Hospital of Philadelphia.

Among his professional affiliations, Dr. Mavroudis is a member of the Children’s Hospital of Philadelphia Wellness Workgroup, the International Society for Nomenclature of Paediatric and Congenital Heart Disease, and the World Society for Pediatric and Congenital Heart Surgery (on the teaching faculty). 

To boot, he is the Associate Program Director of the Congenital Cardiac Surgery Fellowship (2023 – present), an Assistant Professor of Surgery within the Division of Cardiothoracic Surgery at the Perelman School of Medicine at the University of Pennsylvania, an Associate Fellow of the American College of Cardiology, an Early Career Member of the American Heart Association, and a member of the Society of Thoracic Surgeons.

With an unwavering commitment to his specialty, Dr. Mavroudis is board-certified in cardiac and thoracic surgery by the American Board of Thoracic Surgery (ABTS). The ABTS is an American surgical organization devoted to surgery of the chest.

Cardiothoracic surgery is the field of medicine involved in the surgical treatment of organs inside the thorax. Cardiothoracic surgeons are medical doctors who specialize in surgical procedures inside the thorax, which may involve the heart, lungs, esophagus, and other organs in the chest. Alongside performing surgery, they also diagnose and treat diseases of these organs.

Holding editorial positions, Dr. Mavroudis is a guest reviewer for the Journal of Surgical Research, Annals of Thoracic Surgery, the Journal of Cardiovascular and Thoracic Surgery, Nature Scientific Reports, Pediatric Research, the Journal of Cardiovascular Surgery, and the World Journal for Pediatric and Congenital Heart Surgery. He also sits on the editorial board of Cardiology in the Young, and has authored many peer-reviewed papers and textbook chapters.

Among his various accolades include 2023, Thoracic Surgical Foundation Research Grant; 2022, Children’s Hospital of Philadelphia Cardiac Center Innovation Grant; 2022, Children’s Hospital of Philadelphia Academic Enrichment Grant; 2021, McCabe Fund Award Research Grant; 2020, Congenital Heart Disease Coalition Research Grant; 2017, Research Grant, Swine Surgical Training Model; 2017, Young Investigator Award, American Heart Association; 2017, C. Walton Lillehei MD, PhD Young Investigator Award; 2015, Outstanding Investigator Award: Cardiology; 2015, Children’s Hospital of Philadelphia Cardiac Center Research Grant; and 2014, Institution for Translational Medicine and Therapeutics (ITMAT) Scholarship, University of Pennsylvania.

When not teaching, in the laboratory or practicing medicine, Dr. Mavroudis can often be found training for his next marathon or triathlon. He also enjoys sailing, scuba diving, playing squash, hiking and being outdoors.

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