Dr. Sanford J Shattil M.D.
Hematologist-Oncologist | Hematology & Oncology
200 W Arbor Dr Ucsd Medical Center San Diego CA, 92103About
Dr. Sanford Shattil is a hematologist oncologist practicing in San Diego, CA. Dr. Shattil specializes in the diagnosis, treatment and prevention of blood diseases such as anemia, hemophilia, sickle-cell disease, leukemia and lymphoma. Hematologist Oncologists are also trained in the study of cancer and its attack on other organs.
Education and Training
University of Illinois College of Medicine, Chicago, IL Medical Degree
Boston City Hospital, Boston, MA Other Degree
Professor of Medicine Medical Degree
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM- Hematology
Internal MedicineAmerican Board of Internal MedicineABIM
Provider Details
Expert Publications
Data provided by the National Library of Medicine- A mutation in the extracellular cysteine-rich repeat region of the beta3 subunit activates integrins alphaIIbbeta3 and alphaVbeta3.
- Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand.
- Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways.
- Signaling networks linking integrins and rho family GTPases.
- Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors.
- A mechanism for modulation of cellular responses to VEGF: activation of the integrins.
- The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton.
- Ligand binding to integrin alpha(v)beta(3) requires tyrosine 178 in the alpha(v) subunit.
- Integrin activation controls metastasis in human breast cancer.
- Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration.
- All in the family: primary megakaryocytes for studies of platelet alphaIIbbeta3 signaling.
- Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment.
- Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3.
- Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling.
- Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
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