Dr. John H Weiss MD
Neurologist | Neurology
Uci Medical Center 101 The City Drive S Orange CA, 92868About
Dr. John Weiss is a distinguished Neurologist in Orange, CA. Dr. Weiss specializes in diagnosing, treating, and managing disorders of the brain and nervous system. With expertise in handling complex conditions like epilepsy, multiple sclerosis, and migraines, Dr. Weiss employs advanced techniques and personalized treatment plans to improve patient outcomes. As a neurologist, Dr. Weiss is committed to staying abreast of the latest developments in neurological research and therapies.
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Expert Publications
Data provided by the National Library of Medicine- Blockade of Ca2+-permeable AMPA/kainate channels decreases oxygen-glucose deprivation-induced Zn2+ accumulation and neuronal loss in hippocampal pyramidal neurons.
- Mitochondrial sequestration and Ca(2+)-dependent release of cytosolic Zn(2+) loads in cortical neurons.
- Zn2+ currents are mediated by calcium-permeable AMPA/kainate channels in cultured murine hippocampal neurones.
- Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons.
- Modulation of mitochondrial function by endogenous Zn2+ pools.
- A new mitochondrial fluorescent zinc sensor.
- A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells.
- Heterogeneity of Ca2+-permeable AMPA/kainate channel expression in hippocampal pyramidal neurons: fluorescence imaging and immunocytochemical assessment.
- Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis.
- Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons.
- Calcium-permeable AMPA channels in neurodegenerative disease and ischemia.
- BMAA selectively injures motor neurons via AMPA/kainate receptor activation.
- Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS.
- Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels.
- Zn2+ influx is critical for some forms of spreading depression in brain slices.
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