Dr. Michael R Freeman M.D.

Expert Publications

• Activation of the Erk mitogen-activated protein kinase pathway stimulates neuroendocrine differentiation in LNCaP cells independently of cell cycle withdrawal and STAT3 phosphorylation.
• Reversible regional wall motion abnormalities on exercise technetium-99m-gated cardiac single photon emission computed tomography predict high-grade angiographic stenoses.
• Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells.
• The decision to undergo DNA or protein synthesis is determined by the degree of mechanical deformation in human bladder muscle cells.
• Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function.
• Cardiac encasement by metastatic myxoid liposarcoma.
• Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies.
• Transactivation of ErbB1 and ErbB2 receptors by angiotensin II in normal human prostate stromal cells.
• A nuclear form of the heparin-binding epidermal growth factor-like growth factor precursor is a feature of aggressive transitional cell carcinoma.
• Platelet derived growth factor-BB is a potent mitogen for rat ureteral and human bladder smooth muscle cells: dependence on lipid rafts for cell signaling.
• Calcium regulates the PI3K-Akt pathway in stretched osteoblasts.
• Signaling through PI3K/Akt mediates stretch and PDGF-BB-dependent DNA synthesis in bladder smooth muscle cells.
• JNK/SAPK mediates doxorubicin-induced differentiation and apoptosis in MCF-7 breast cancer cells.
• Endocardial cryotherapy as a novel strategy of improving myocardial perfusion in a patient with severe coronary artery disease.
• Involvement of cholesterol-rich lipid rafts in interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells.

Media Releases

Get to know Gastroenterologist Dr. Michael R. Freeman, who serves patients in Cape Girardeau, Missouri.

Dr. Freeman is a highly-trained gastroenterologist serving as the Founder of The Freeman Clinic in Cape Girardeau, Missouri. Enjoying the personal care he is able to provide, he treats most gastro-related diseases and specializes in gastroenterology and internal medicine.

As an independent medical provider, he is allowed to assist each patient in choosing the highest quality service provider while ensuring the lowest possible cost.

“The Freeman Clinic is, well… A clinic! By definition, a clinic is a place where medical care is provided in an outpatient setting. Our goal is to provide the best quality, most comprehensive care at the lowest possible cost. Hospitals are very expensive, and our goal is to provide your care in an outpatient setting if at all possible” as stated on the practice’s website. 

A 1977 graduate of the University of Tennessee Health Science Center College of Medicine, Dr. Freeman went on to perform his internship, residency in internal medicine, and fellowship in gastroenterology at the said establishment. 

Having been practicing medicine for over four decades, the doctor is board-certified in gastroenterology and internal medicine by the American Board of Internal Medicine (ABIM). The ABIM is a physician-led, non-profit, independent evaluation organization driven by doctors who want to achieve higher standards for better care in a rapidly changing world.

In his professional experience, Dr. Freeman is affiliated with Saint Francis Medical Center and Missouri Delta Medical Center.

Gastroenterology is the branch of medicine focused on the digestive system and its disorders. A gastroenterologist is a physician who has extensive training in the diagnosis and treatment of disorders related to the esophagus, stomach, small intestines, colon, liver, pancreas, and biliary system.

Among Dr. Freeman’s most notable achievements include On-Time Doctor Award (2016, 2017, 2018), Patients’ Choice Award (2017, 2018), and Compassionate Doctor Recognition (2017, 2018).

On a more personal note, he resides in Cape Girardeau with his wife, Jodi.

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