Dr. Robert S Negrin M.D.
Hematologist (Blood Specialist) | Hematology
300 Pasteur Dr. H3249, Mc 5623 Room H3249 Stanford CA, 94305About
Dr. Robert Negrin is a hematology internist practicing in Stanford, CA. Dr. Negrin specializes in cases of suspected blood disorders when a diagnosis is unclear and further medical care is needed. Hematology internists work with other specialists such as surgeons, radiation therapists and gynecologists in order to get a better understanding on the cases. Often, patients are asked to participate in clinical research that could result in more efficient treatment methods.
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM- Hematology
Internal MedicineAmerican Board of Internal MedicineABIM- 1987
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Engraftment of chronic myeloid leukemia in SCID mice.
- Visualizing the kinetics of tumor-cell clearance in living animals.
- A feasibility study of multiple cycle therapy with melphalan, thiotepa, and paclitaxel followed by mitoxantrone, thiotepa, and paclitaxel with autologous hematopoietic cell support for metastatic breast cancer.
- Use of reporter genes for optical measurements of neoplastic disease in vivo.
- Noninvasive assessment of tumor cell proliferation in animal models.
- Resistance of ex vivo expanded CD3+CD56+ T cells to Fas-mediated apoptosis.
- Favorable treatment outcome in non-Hodgkin's lymphoma patients with "poor" mobilization of peripheral blood progenitor cells.
- CD2-mediated IL-12-dependent signals render human gamma delta-T cells resistant to mitogen-induced apoptosis, permitting the large-scale ex vivo expansion of functionally distinct lymphocytes: implications for the development of adoptive immunotherap
- CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56+ T cells.
- Survivin expression correlates with apoptosis resistance after lymphocyte activation and is found preferentially in memory T cells.
- Expansion of cytotoxic CD3+ CD56+ cells from peripheral blood progenitor cells of patients undergoing autologous hematopoietic cell transplantation.
- Rapid engraftment after allogeneic transplantation of density-enriched peripheral blood CD34+ cells in patients with advanced hematologic malignancies.
- CD31 mismatching affects marrow transplantation outcome.
- Hodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis.
Clinical Trials
Fellowships
- Stanford University School of Medicine,Stanford, Ca, United States 1987
Publications
- PloS oneRole of lymphocyte activation gene-32014
- BloodRegulatory T cells and tural killer T cells for modulation of GVHD following allogeneic2013
- BLOODA distinct evolution of the T2013
- jourl of clinical investigationMapping immune processes in intact tissues at cellular resolution.2012
- JOURL OF CLINICAL INVESTIGATIONMapping immune processes in intact tissues at cellular resolution2012
- PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMCo-transplantation of pure blood stem cells with antigen2012
- BLOODLow doses of tural killer T cells provide protection from acute graft-versus2011
- BONE MARROW TRANSPLANTATIONLong-term outcomes in patients with high2011
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONtural and Expanded CD4(+) CD25(+) Regulatory T Cells in Bone Marrow Transplantation2011
- Garrote, A. L., Brede, C., Baeuerlein, C., Riedel, S., Kiesel, C., GreCD11B+CD11C+DENDRITIC CELLS INTERACT WITH ALLOREACTIVE T CELLS IN THE INTESTIL MUCOSA IN ACUTE2010
- CURRENT OPINION IN ONCOLOGYBiology and clinical effects of tural killer cells in allogeneic transplantation2010
- JOURL OF CLINICAL ONCOLOGYImmunoglobulin G Fc Receptor Fc gamma RIIIa 158 V2010
- JOURL OF IMMUNOLOGYTissue-Specific Homing and Expansion of Donor NK Cells in Allogeneic Bone Marrow Transplantation2009
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONtural Killer Cells in Allogeneic Transplantation: Effect on Engraftment, Graft- versus-Tumor2009
- IMMUNOLOGYRegulation of different inflammatory diseases by impacting the mevalote pathway2009
- PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMGlycogen synthase kise 3 beta missplicing contributes to leukemia stem cell generation2009
- INTERTIOL JOURL OF CANCERFollicular lymphoma B cells induce the conversion of conventiol CD42009
- JOURL OF IMMUNOLOGYImpact of mammalian target of rapamycin inhibition on lymphoid homing2008
- JOURL OF IMMUNOLOGYPlasmacytoid dendritic cells take up opsonized antigen leading to CD4(+)2008
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONHost-derived interleukin-18 differentially impacts regulatory2007
- AMERICAN JOURL OF OBSTETRICS AND GYNECOLOGYA novel technique for the enrichment of primary ovarian cancer cells2007
- JOURL OF IMMUNOLOGYCD101 surface expression discrimites potency among murine FoxP3(+) regulatory T cells2007
- BLOODIn vivo dymics of regulatory T-cell trafficking2007
- BLOODEarly CD30 sigling is critical for adoptively transferred CD4(+)CD25(+) regulatory T cells2007
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONRole of turally arising regulatory T cells in hematopoietic cell transplantation2006
- ture reviews. ImmunologyIn vivo imaging using bioluminescence: a tool for probing graft-versus-host disease.2006
- TURE REVIEWS IMMUNOLOGYInnovation - In vivo imaging using bioluminescence: a tool for probing graft-versus-host disease2006
- NEW ENGLAND JOURL OF MEDICINEProtective conditioning for acute graft-versus-host disease - Reply2005
- JOURL OF IMMUNOLOGYSilencing human NKG2D, DAP102005
- AMERICAN JOURL OF PATHOLOGYEx vivo expanded dendritic cells home to T2005
- NEW ENGLAND JOURL OF MEDICINEProtective conditioning for acute graft-versus-host disease2005
- BLOODIn vivo alyses of early events in acute graft-versus2005
- BLOODRole of NKG2D sigling in the cytotoxicity of activated and expanded CD8(+) T cells2004
- TURE MEDICINECD4(+)CD25(+) regulatory T cells preserve graft-versus2003
- EUROPEAN JOURL OF CANCERAdvancing animal models of neoplasia through in vivo bioluminescence imaging2002
- CANCER RESEARCHVisualization of effective tumor targeting by CD8+tural killer T cells redirected with bispecific2002
- JOURL OF CLINICAL IMMUNOLOGYStudies of ex vivo activated and expanded CD8(+) NK-T cells in humans and mice2002
- JOURL OF CELLULAR BIOCHEMISTRYUnderstanding immune cell trafficking patterns via in vivo bioluminescence imaging2002
- ANLS OF HEMATOLOGYVisualization of tumor growth and response to NK-T cell based immunotherapy using bioluminescence2002
- INTERTIOL JOURL OF CANCERHodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kise show growth2001
- BLOODExpansion of cytolytic CD82001
- NEW ENGLAND JOURL OF MEDICINETransplantation of bone marrow as compared with peripheral-blood cells from HLA2001
- BLOODCD2-mediated IL-12-dependent sigls render human gamma delta-T cells resistant to mitogen-induced2000
- JOURL OF PARENTERAL AND ENTERAL NUTRITIONEffect of oral glutamine supplementation during bone marrow transplantation0
- Biology of blood and marrow transplantationTotal lymphoid irradiation-antithymocyte globulin conditioning2014
- BloodDonor hematopoiesis in mice following total lymphoid irradiation requires host T2014
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONOptimizing Autologous Stem Cell Mobilization Strategies to Improve Patient Outcomes2014
- PloS oneRole of lymphocyte activation gene-32014
- BloodMast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells.2013
- Biology of blood and marrow transplantationIL-17 Gene Ablation Does Not Impact Treg2013
- BloodRegulatory T cells and natural killer T cells for modulation of GVHD following allogeneic2013
- BLOODA distinct evolution of the T2013
- BLOODA new approach for eradication of residual lymphoma cells by host nonreactive anti-third2013
- BLOODMurine anti-third-party central-memory CD82013
- BMC medicineA diagnostic window for the treatment of acute graft-versus2013
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONCancer Vaccines and T Cell Therapy2013
- journal of clinical investigationMapping immune processes in intact tissues at cellular resolution.2012
- JOURNAL OF CLINICAL INVESTIGATIONMapping immune processes in intact tissues at cellular resolution2012
- BLOODProphylactic rituximab after allogeneic transplantation decreases B2012
- BLOODRapid development of exhaustion2012
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OCo-transplantation of pure blood stem cells with antigen2012
- BONE MARROW TRANSPLANTATIONSirolimus and mycophenolate mofetil as GVHD prophylaxis in myeloablative2012
- BONE MARROW TRANSPLANTATIONTandem chemo-mobilization followed by high2012
- BLOODLong-term outcomes after transplantation of HLA2012
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONCytomegalovirus Viral Load2012
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONLong-Term Outcome of Patients with Metastatic Breast Cancer Treated with High-Dose Chemotherapy2012
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONAdoptive Immunotherapy with Cytokine2011
- BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGYRole of regulatory T cell populations in controlling graft vs host disease2011
- BLOODRapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased2011
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONAutologous versus Reduced2011
- BLOODLow doses of natural killer T cells provide protection from acute graft-versus2011
- BLOODCD8(+)CD44(hi) but not CD4(+)CD44(hi) memory T cells mediate potent graft antilymphoma activity2011
- CELL STEM CELLShort-Term Immunosuppression Promotes Engraftment of Embryonic and Induced Pluripotent Stem Cells2011
- BONE MARROW TRANSPLANTATIONLong-term outcomes in patients with high2011
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONNatural and Expanded CD4(+) CD25(+) Regulatory T Cells in Bone Marrow Transplantation2011
- CANCER RESEARCHCXCL12 Mediates Immunosuppression2010
- CANCER RESEARCHDefinition of an Enhanced Immune Cell Therapy in Mice That Can Target Stem-Like Lymphoma Cells2010
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONPhase I/II Trial of GN-BVC2010
- Garrote, A. L., Brede, C., Baeuerlein, C., Riedel, S., Kiesel, C., GreCD11B+CD11C+DENDRITIC CELLS INTERACT WITH ALLOREACTIVE T CELLS IN THE INTESTINAL MUCOSA IN ACUTE2010
- Baeuerlein, C., Riedel, S., Brede, C., Garrote, A. L., Kiesel, C., RitDIFFERENCES IN ALLOREACTIVE T CELL MIGRATION IN MHC MATCHED VERSUS MHC MISMATCHED HCT2010
- BLOODNK cells mediate reduction of GVHD by inhibiting activated2010
- Beilhack, A., Baker, J., Riedel, S., Brede, C., Baeuerlein, C. A., JorSimultaneous blockade of several endothelial lig2010
- CURRENT OPINION IN ONCOLOGYBiology and clinical effects of natural killer cells in allogeneic transplantation2010
- BONE MARROW TRANSPLANTATIONLong-term follow-up of patients with diffuse large B-cell non-Hodgkin's lymphoma receiving purged2010
- JOURNAL OF CLINICAL ONCOLOGYImmunoglobulin G Fc Receptor Fc gamma RIIIa 158 V2010
- STEM CELLSDirect Imaging of Immune Rejection and Memory Induction by Allogeneic Mesenchymal Stromal Cells2009
- JOURNAL OF IMMUNOLOGYTissue-Specific Homing and Expansion of Donor NK Cells in Allogeneic Bone Marrow Transplantation2009
- BLOODTLI and ATG conditioning with low risk of graft-versus2009
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONNatural Killer Cells in Allogeneic Transplantation: Effect on Engraftment, Graft- versus-Tumor2009
- IMMUNOLOGYRegulation of different inflammatory diseases by impacting the mevalonate pathway2009
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OGlycogen synthase kinase 3 beta missplicing contributes to leukemia stem cell generation2009
- INTERNATIONAL JOURNAL OF CANCERFollicular lymphoma B cells induce the conversion of conventional CD42009
- JOURNAL OF IMMUNOLOGYImpact of mammalian target of rapamycin inhibition on lymphoid homing2008
- BLOODIn vivo trafficking2008
- JOURNAL OF IMMUNOLOGYPlasmacytoid dendritic cells take up opsonized antigen leading to CD4(+)2008
- BLOODLong-term remission of Philadelphia chromosome2008
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONLong-term results of autologous hematopoietic cell transplantation for peripheral T cell lymphoma2008
- BLOODPrevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs2008
- CELL CYCLEInterleukin-2 receptor downstream events in regulatory T cells2008
- BLOODThe impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation2008
- BLOODDifferential impact of mammalian target of rapamycin inhibition on CD4(+)CD25(+)Foxp3(+)2008
- BLOODPreemptive HMG-CoA reductase inhibition provides graft2007
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONHost-derived interleukin-18 differentially impacts regulatory2007
- AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGYA novel technique for the enrichment of primary ovarian cancer cells2007
- JOURNAL OF IMMUNOLOGYCD101 surface expression discriminates potency among murine FoxP3(+) regulatory T cells2007
- BLOODIn vivo dynamics of regulatory T-cell trafficking2007
- BLOODEarly CD30 signaling is critical for adoptively transferred CD4(+)CD25(+) regulatory T cells2007
- BLOODThe effects of imatinib mesylate treatment before allogeneic transplantation for chronic myeloid2007
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONPromise and challenges of human regulatory T cells in the clinic2007
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONRole of naturally arising regulatory T cells in hematopoietic cell transplantation2006
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONHigh-dose carmustine, etoposide2006
- BLOODInhibition of CD4(+)CD25(+) regulatory T-cell function by calcineurin2006
- Nature reviews. ImmunologyIn vivo imaging using bioluminescence: a tool for probing graft-versus-host disease.2006
- NATURE REVIEWS IMMUNOLOGYInnovation - In vivo imaging using bioluminescence: a tool for probing graft-versus-host disease2006
- Current stem cell research & therapyAcute graft-versus-host disease-challenge for a broader application of allogeneic hematopoietic2006
- SCIENCESynergistic antitumor effects of immune cell-viral biotherapy2006
- CLINICAL CANCER RESEARCHEnhanced killing of primary ovarian cancer by retargeting autologous cytokine2006
- CYTOTHERAPYThe apoptotic and proliferative fate of cytokine2006
- CURRENT OPINION IN ORGAN TRANSPLANTATIONTotal lymphoid irradiation and transplantation tolerance2006
- NEW ENGLAND JOURNAL OF MEDICINEProtective conditioning for acute graft-versus-host disease - Reply2005
- JOURNAL OF IMMUNOLOGYSilencing human NKG2D, DAP102005
- AMERICAN JOURNAL OF PATHOLOGYEx vivo expanded dendritic cells home to T2005
- NEW ENGLAND JOURNAL OF MEDICINEProtective conditioning for acute graft-versus-host disease2005
- BLOODIn vivo analyses of early events in acute graft-versus2005
- TRANSPLANTATIONMolecular imaging using labeled donor tissues reveals patterns of engraftment, rejection2005
- CLINICAL CANCER RESEARCHLow levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine2005
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONA phase I trial of autologous cytokine2005
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONRandomized trial of allogeneic related bone marrow transplantation versus peripheral blood stem2005
- ANNUAL REVIEW OF MEDICINEHematopoietic stem and progenitor cells2005
- BLOODRole of NKG2D signaling in the cytotoxicity of activated and expanded CD8(+) T cells2004
- METHODSEvaluation of effector cell fate and function by in vivo bioluminescence imaging2003
- NATURE MEDICINECD4(+)CD25(+) regulatory T cells preserve graft-versus2003
- BLOODRevealing lymphoma growth2003
- EUROPEAN JOURNAL OF CANCERAdvancing animal models of neoplasia through in vivo bioluminescence imaging2002
- CANCER RESEARCHVisualization of effective tumor targeting by CD8+natural killer T cells2002
- JOURNAL OF CLINICAL IMMUNOLOGYStudies of ex vivo activated and expanded CD8(+) NK-T cells in humans and mice2002
- JOURNAL OF CELLULAR BIOCHEMISTRYUnderstanding immune cell trafficking patterns via in vivo bioluminescence imaging2002
- ANNALS OF HEMATOLOGYVisualization of tumor growth and response to NK-T cell based immunotherapy using bioluminescence2002
- EXPERIMENTAL HEMATOLOGYBioluminescence imaging of lymphocyte trafficking in vivo2001
- INTERNATIONAL JOURNAL OF CANCERHodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth2001
- CANCERRapid engraftment after allogeneic transplantation of density2001
- BLOODExpansion of cytolytic CD82001
- IMMUNOLOGY LETTERSSurvivin expression correlates with apoptosis resistance after lymphocyte activation2001
- CANCER IMMUNOLOGY IMMUNOTHERAPYCD58/LFA-3 and IL-12 provided by activated monocytes2001
- NEW ENGLAND JOURNAL OF MEDICINETransplantation of bone marrow as compared with peripheral-blood cells from HLA2001
- BLOODHigh-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first2001
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONHigh-dose therapy and autologous hematopoietic2001
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONExpansion of cytotoxic CD3(+)CD56(+) cells from peripheral blood progenitor cells of patients2001
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONCD31 mismatching affects marrow transplantation outcome2001
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONEfficacy and toxicity of a CCNU-containing high2001
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONEngineering hematopoietic grafts2001
- BLOODCD2-mediated IL-12-dependent signals render human gamma delta-T cells resistant to mitogen-induced2000
- CANCER IMMUNOLOGY IMMUNOTHERAPYResistance of ex vivo expanded CD3(+)CD56(+) T cells to Fas-mediated apoptosis2000
- JOURNAL OF PARENTERAL AND ENTERAL NUTRITIONEffect of oral glutamine supplementation during bone marrow transplantation0
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