Dr. Geoffrey I. Shapiro MD PHD
Oncologist | Medical Oncology
450 Brookline Avenue Mayer 446 Boston Massachusetts, 07715Rating
4/5
About
PhD-Cornell University School of Science
Director of the Early Drug Development Center.
Education and Training
Cornell University
Jawaharlal Institute of Post Graduate Medicine Research, Pondicherry University 1988
Board Certification
Oncology
Medicine
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer.
- Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase.
- Flavopiridol-induced apoptosis during S phase requires E2F-1 and inhibition of cyclin A-dependent kinase activity.
- Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol.
- A phase II clinical and pharmacodynamic study of E7070 in patients with metastatic, recurrent, or refractory squamous cell carcinoma of the head and neck: modulation of retinoblastoma protein phosphorylation by a novel chloroindolyl sulfonamide cell
- Flavopiridol reduces malignant transformation of the esophageal mucosa in p27 knockout mice.
- Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins.
- AZ703, an imidazo[1,2-a]pyridine inhibitor of cyclin-dependent kinases 1 and 2, induces E2F-1-dependent apoptosis enhanced by depletion of cyclin-dependent kinase 9.
- Cyclin-dependent kinase pathways as targets for cancer treatment.
- Epidermal growth factor receptor variant III mutations in lung tumorigenesis and
- Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272.
- The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function.
- Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells.
- Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling.
- Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy.
Clinical Trials
- Study of the CDK4/6 Inhibitor Abemaciclib in Solid Tumors Harboring Genetic Alterations in Genes Encoding D-type Cyclins or Amplification of CDK4 or CDK6
- Study of the CDK4/6 Inhibitor Palbociclib (PD-0332991) in Combination With the MEK Inhibitor Binimetinib (MEK162) for Patients With Advanced KRAS Mutant Non-Small Cell Lung Cancer
- Dose Finding Study of TNO155 in Adult Patients With Advanced Solid Tumors
- A Study of LY3321367 Alone or With LY3300054 in Participants With Advanced Relapsed/Refractory Solid Tumors
- A Study of LY2606368 (Prexasertib) in Patients With Solid Tumors With Replicative Stress or Homologous Repair Deficiency
- Study CB-839 in Combination With Nivolumab in Patients With Melanoma, ccRCC and NSCLC
- Study of Safety and Efficacy of Ribociclib and Trametinib in Patients With Metastatic or Advanced Solid Tumors
- OLAParib COmbinations
- Phase I Study of Pyrotinib in Patients With HER2-positive Solid Tumors
- Study of ASTX029 in Subjects With Advanced Solid Tumors
Areas of expertise and specialization
Internships
- Beth Israel Medical Center
Fellowships
- Dana Farber Cancer Institute
Professional Society Memberships
- American Society of Clinical Oncology, American Association Cancer Research, Internal Association of the Study of Lung Cancer
What do you attribute your success to?
Hard work and excellent patient care.
Teaching and speaking
Assistant Professor at Harvard University and Dana Farber Cancer Institute.
Hobbies / Sports
- Reading
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