Dr. Thomas J Simpson MD
Pediatrician
120 Magellan Ave San Francisco CA, 94116About
Dr. Thomas Simpson is a pediatrician practicing in San Francisco, CA. Dr. Simpson is a doctor who specializes in the health care of children. As a pedicatrician, Dr. Simpson diagnoses and treats infections, injuries, diseases and other disorders in children. Pediatricians typically work with infants, children, teenagers and young adults up to age 21. They practice medical care as well as preventative health care. Dr. Simpson can oversee and manage the physical, mental and emotional health of their patients.
Education and Training
Univ of Ca, San Francisco, Sch of Med, San Francisco Ca 1981
University of California 1981
Board Certification
PediatricsAmerican Board of PediatricsABP
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Kinetic and mechanistic analysis of the malonyl CoA:ACP transacylase from Streptomyces coelicolor indicates a single catalytically competent serine nucleophile at the active site.
- Synthesis and characterisation of acyl carrier protein bound polyketide analogues.
- Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.
- Solution structure and dynamics of oxytetracycline polyketide synthase acyl carrier protein from Streptomyces rimosus.
- The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs.
- Synthesis and incorporation of the first polyketide synthase free intermediate in monocerin biosynthesis.
- Expression, purification and preliminary X-ray diffraction analysis of a ketoreductase from a type II polyketide synthase.
- The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding.
- Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis.
- Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series.
- Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster.
- Assembly intermediates in polyketide biosynthesis: enantioselective syntheses of beta-hydroxycarbonyl compounds.
- Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE.
- Self-malonylation is an intrinsic property of a chemically synthesized type II polyketide synthase acyl carrier protein.
- The malonyl transferase activity of type II polyketide synthase acyl carrier proteins.
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UCSF MEDICAL CENTERl
505 PARNASSUS AVE, BOX 0296 SAN FRANCISCO CA 94143ST MARY'S MEDICAL CENTERl
450 STANYAN ST SAN FRANCISCO CA 94117