Dr. William T. Tse, MD, PhD

Expert Publications

• Red blood cell membrane disorders.
• The human ankyrin-1 gene is selectively transcribed in erythroid cell lines despite the presence of a housekeeping-like promoter.
• Large numbers of alternatively spliced isoforms of the regulatory region of human erythrocyte ankyrin.
• Polymerase chain reaction analysis of an NcoI polymorphism of the human erythrocyte ankyrin gene.
• Isolation and chromosomal localization of a novel nonerythroid ankyrin gene.
• A splice site mutation of the beta-spectrin gene causing exon skipping in hereditary elliptocytosis associated with a truncated beta-spectrin chain.
• A defect in alpha-spectrin mRNA accumulation in hereditary pyropoikilocytosis.
• Age-dependent pharmacokinetic profile of single daily dose i.v. busulfan in children undergoing reduced-intensity conditioning stem cell transplant.
• Bistable switches control memory and plasticity in cellular differentiation.
• High WT1 gene expression before haematopoietic stem cell transplant in children with acute myeloid leukaemia predicts poor event-free survival.
• Point mutation in the beta-spectrin gene associated with alpha I/74 hereditary elliptocytosis. Implications for the mechanism of spectrin dimer self-association.
• Full-length sequence of the cDNA for human erythroid beta-spectrin.
• Clinical and molecular aspects of disorders of the erythrocyte membrane skeleton.
• Reverse transcription and direct amplification of cellular RNA transcripts by Taq polymerase.
• Single Daily Busulfan Dosing for Infants with Nonmalignant Diseases Undergoing Reduced-Intensity Conditioning for Allogeneic Hematopoietic Progenitor Cell Transplantation.

Media Releases

Get to know Hematologist-Oncologist Dr. William T. Tse, who serves patients in Cleveland, Ohio.

Dr. Tse is a board certified hematologist-oncologist who has recently joined MetroHealth Medical Center as Director in the Division of Hematology/Oncology and Deputy Director of the MetroHealth Cancer Center. He is also a Clinical Professor in the Department of Medicine at Case Western Reserve University School of Medicine, as well as member of the Immune Oncology Program at Case Comprehensive Cancer Center. He has previously served as Professor and Chief of the Division of Blood and Bone Marrow Transplantation at Jame Graham Brown Cancer Center at the University of Louisville School of Medicine in Louisville, Kentucky (2014-2020).

Dr. Tse received his medical degree in 1986 at Sun Yat Sen University School of Medicine in China. He then moved to Canada, where he performed a research fellowship in medical biophysics and molecular hematology at the Ontario Cancer Institute and Princess Margaret Hospital at the University of Toronto (1990-1192), as well as a research fellowship in immunology and cancer at The Hospital For Sick Children/University of Toronto (1992-1995). 

Dr. Tse relocated to the United States and for a clinical pathology training at North Shore University Hospital/New York University School of Medicine. He served his residency in internal medicine at Long Island Jewish Medical Center (1997-2000), followed by his fellowship in medical oncology and bone marrow transplantation conducted at the Fred Hutchinson Cancer Research Center/University of Washington School of Medicine (2000-2003). In 2018, he received an MBA degree from the University of Louisville.

Following his training, he attained board certification in internal medicine, medical oncology, and hematology through the American Board of Internal Medicine (ABIM). The American Board of Internal Medicine is a 501 nonprofit, self-appointed physician-evaluation organization that certifies physicians practicing internal medicine and its subspecialties. The American Board of Internal Medicine is not a membership society, educational institution, or licensing body.

Hematology is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood. It involves treating diseases that affect the production of blood and its components, such as blood cells, hemoglobin, blood proteins, bone marrow, platelets, blood vessels, spleen, and the mechanism of coagulation. Such diseases might include hemophilia, blood clots (thrombus), other bleeding disorders, and blood cancers such as leukemia, multiple myeloma, and lymphoma.

Oncology is the study of cancer. The field of oncology has three major areas: medical, surgical, and radiation. A medical oncologist treats cancer using chemotherapy or other medications, such as targeted therapy or immunotherapy. A surgical oncologist removes the tumor and nearby tissue during surgery. A radiation oncologist treats cancer using radiation therapy.

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