Dr. Lawrence B Holzman MD
Nephrologist (Kidney Specialist) | Nephrology
3400 Civic Center Blvd 1st Floor, Suite 300 Philadelphia PA, 19104About
Dr. Lawrence Holzman is a nephrologist practicing in Philadelphia, PA. Dr. Holzman specializes in the care and treatment of the kidneys. As a nephrologist, Dr. Holzman most typically treats conditions like kidney stones, chronic kidney disease, acute renal failure, polycystuc kidney disease, high blood pressure and more. Nephrologists are also experts on kidney transplantation and dialysis. They are usually referred to by primary care physicians for problems related to the kidneys, and while they can perform tests to diagnose kidney disorders, they do not perform surgeries.
Education and Training
Umdnj-New Jersey Med Sch- Newark Nj 1984
Rutgers 1984
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM
Provider Details
Expert Publications
Data provided by the National Library of Medicine- The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate.
- Cloning and expression of the rat nephrin homolog.
- Nephrin localizes to the slit pore of the glomerular epithelial cell.
- Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein.
- Identification of structural and functional domains in mixed lineage kinase dual leucine zipper-bearing kinase required for complex formation and stress-activated protein kinase activation.
- Evaluation of a new tool for exploring podocyte biology: mouse Nphs1 5' flanking region drives LacZ expression in podocytes.
- Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components.
- Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation.
- Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin.
- Two gene fragments that direct podocyte-specific expression in transgenic mice.
- Podocyte-specific expression of cre recombinase in transgenic mice.
- Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers.
- Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin.
- Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation.
- Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis.
Clinical Trials
Treatments
- Chronic Kidney Disease
- Lupus
- Peripheral Artery Disease (pad)
- Vascular Disease
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