“How do you relieve pain from a ganglion cyst?”

Generally ganglion cysts do not cause pain so if you are having pain in the region of the ganglion cyst you need to be evaluated to determine what is actually causing it. Safe bet would be to try NSAIDs (Non-steroidal anti-inflammatory medications). Over the counter you are limited to Aleve vs. Ibuprofen (Ibuprofen/Motrin/Advil are all the same). Aleve is easier to take. Follow the instructions on the bottle.

Typically, aspiration via needle or surgical excision.

Dr. D

So sorry your having pain, I assume in your wrist. Ganglion cysts can occur in many places of the body. They occur because of a break in the connection between 2 ligaments and are actually protective when a part of a joint is injured or overused. There are a lot of nerves in the wrist that get stretched because of the ganglion cyst.
I am sure you have looked up that in the old days, they used to get rid of the ganglion cyst by taking the bible and smashing it on the wrist. Unfortunately if you come to a doctors office and they drain the ganglion cyst with a needle, the ganglion cyst usually comes back. Temporarily you can rub some Voltaren Gel or anti-inflammatory cream on the ganglion cyst but when you have a ganglion cyst that hurts a lot it may be time to visit us or your orthopaedic surgeon.

Start with ice and anti inflammatories like ibuprofen or alive. If that doesn't work, then it can be drained at a doctor's office.