Genetics and Pharmacology
Marci (Marquita) Catallo-Madruga is a physical therapist practicing in Centennial, CO. Dr. Marci specializes in physical treatment to help a patient reduce pain, restore mobility, rehabilitate an injury, or increase movement and overall function. As a physical therapist, Marquita Catallo-Madruga can treat multiple conditions... more
Ever Had a bad experience with a Prescription?
Ever thought it was an allergic reaction to a medication?
In 2017 I had a significant abdominal surgery that required me to take pain medication, anti-inflammatories, and Antibiotics. The Surgery was supposed to help with a significant abdominal umbilical hernia. Surgery was on a Wednesday, and by Monday, I was having a significant reaction to the Pain medication where my FACE went NUMB. Talk about scary.
Leading up to the surgery, I had taken part in 2 appointments where I discussed previous bad reactions to the pain medication and talked about my concerns. They told me it was a necessary evil in this case so that I could sleep. On the Morning of Surgery, after a long discussion with the Anesthesiologist, He asked If I had testing done to look at my response to different drugs. At that time, I didn’t even know that was a thing that could be done.
The News media and Medical Media lately have talked a lot about epigenetics, Epigenomics and now, we are starting to hear about pharmacogenetics. Pharmacogenetics can be done through DNA testing to specifically look at your genetics and how they might react to specific types of drugs. They can allow for better dosing, and better drug choice, so there is less guesswork And overall better outcomes. Pharmacogenetics can also help in looking at how some people may become addicted and others, not to things like Marijuana, which the Prop 64 group in Colorado would have us believe is not possible.
Pharmacogenetics can also let us know when it might be time to change a drug, because the Epigenetics/Epigenomics, or the Environmental Factors that cause the genes to change, may have been affected over the long-term use of specific drugs. These drugs can be related to addiction treatment, Pain Management, Mental Health Disorders (Bipolar, Schizophrenia, Depression), and Autoimmune Logical Drugs including Chemotherapy.
Along the line of Epigenetics/Epigenomics, there is specific testing that can be done that supports your DNA sections. It looks at what will optimally support your health and with that information, we can create a supplement that is SPECIFIC to you. Repeating the test about 6 months after initial testing and consuming those supplements is recommended due to the changes you could potentially make. Then every year.
Why would you need a DNA-specific supplement? Colorado has one of the highest levels of radiation exposure in the continental US. Specifically, we have a lot of naturally occurring Uranium and Radon. Both of those are known carcinogens. Also, think about how much and what type of sunscreen you apply every year in Colorado while enjoying the outdoor lifestyle you love. Chemical Barriers are more likely to interact with the radiation from the sun to create mutation of cells. It starts at the Skin level but quickly spreads to the body as the skin is an organ that ABSORBS things you put on it.
If you have questions about how DNA Testing can improve your health, life, and longevity, Don’t Hesitate to reach out!
References:
*https://dnalife.academy/dna-health/
*Recent developments in genetic/genomic medicine, Rachel H. Horton and Anneke M. Lucassen, Clin Sci (Lond). 2019 Mar 15; 133(5): 697–708.Published online 2019 Mar 5. Prepublished online 2019 Feb 27. doi: 10.1042/CS20180436
*Pharmacogenomics in the treatment of mood disorders: Strategies and Opportunities for personalized psychiatry; Azmeraw T. Amare,1 Klaus Oliver Schubert,1,2 and Bernhard T. Baune1; EPMA J. 2017 Sep; 8(3): 211–227.Published online 2017 Sep 5. doi: 10.1007/s13167-017-0112-8
*Future Trends in the Pharmacogenomics of Brain Disorders and Dementia: Influence of APOE and CYP2D6 Variants; Ramón Cacabelos,1,2,* Lucía Fernández-Novoa,1,2 Rocío Martínez-Bouza,1,2 Adam McKay,1,2 Juan C. Carril,1,2 Valter Lombardi,1,2 Lola Corzo,1,2 Iván Carrera,1,2 Iván Tellado,1,2 Laura Nebril,1,2 Margarita Alcaraz,1,2 Susana Rodríguez,1,2 Ángela Casas,1,2 Verónica Couceiro,1,2 and Antón Álvarez1,2Pharmaceuticals (Basel). 2010 Oct; 3(10): 3040–3100.Published online 2010 Sep 29. doi: 10.3390/ph3103040
*Some observations on the role of environment and genetics in behaviour of wild and domestic forms of Sus scrofa (European wild boars and domestic pigs)S Robert, J Dancosse, A Dallaire – Applied Animal Behaviour Science, 1987 – Elsevier
