Comfort Pac Tizanidine

Brand name:

Comfort Pac Tizanidine, Zanaflex, Zanaflex Capsule.

Tizanidine is a central alpha2-adrenergic agonist used to help relax certain muscles in your body.

This drug relieves spasms, cramping, and tightness of the muscles caused by multiple sclerosis or certain injuries to the spine.

This drug acts on the central nervous system to produce its muscle relaxant effects. This drug requires a prescription.

Before taking this drug, the risks and benefits for your body should be discussed with your healthcare provider.

Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals.

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications.

Studies in the pediatric population on the relationship of age to the effects of oral nicotine have not been performed while safety and efficacy have not been established.

Studies in the elderly have not reported any geriatrics-specific problems that would limit the usefulness of tizanidine.

Caution is required when giving this drug to the elderly since they are more likely to have kidney problems.

Adverse effects have been reported in animal studies but studies in pregnant women and animals are still inadequate. Infant risk is still undetermined when taking this drug during breastfeeding.

Discuss with your healthcare professional about the risks and benefits of this drug before breastfeeding.

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other drugs such as Acyclovir, cimetidine, famotidine, ticlopidine, zileuton, birth control pills, antibiotics, blood pressure medications such as clonidine, guanabenz, guanfacine, methyldopa, or heart rhythm medications such as amiodarone, mexiletine, propafenone, and verapamil.

Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects.

Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco. Inform your healthcare provider for any other medical problems such as kidney or liver diseases.

This drug must be taken exactly as directed by your healthcare professional. To prevent any side effects, take this drug exactly as directed on the label or as prescribed by your healthcare professional.

Follow the instructions on the label or as directed by your healthcare professional. The dose of this drug will be variable for different patients.

The directions on the label or the prescription by your healthcare professional should be followed. The dosage of this drug you take depends on the medical problem for which you are using this drug.

For muscle relaxation in adults, 2 milligrams (mg) every 6 to 8 hours is initially given. The dose must not exceed 36 mg within a 24-hour period.

Use and dose in children must be determined by your healthcare professional. A missed dose should be taken as soon as possible.

However, skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose.

Store the drug in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children.

Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs.

Your health care provider should closely monitor the effectiveness of this drug as well as check for unwanted effects. Unwanted effects can be screened by blood tests.

Check with your healthcare professional before you take any other drugs such as ciprofloxacin or fluvoxamine to prevent unwanted effects.

Consult with your healthcare professional immediately if you experience symptoms of a liver problem such as pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin.

This drug potentiates the effects of alcohol and other CNS depressants such as antihistamines or drug for hay fever, other allergies, or colds, sedatives, tranquilizers, or sleeping drug, prescription pain drug or narcotics, barbiturates, a drug for seizures, other muscle relaxants, or anesthetics, including some dental anesthetics.

This drug may cause dizziness, drowsiness, lightheadedness, clumsiness or unsteadiness, or vision problems in some people.

Be careful in taking this drug before you drive, use machines, or do anything else that could be dangerous if you are not alert, well-coordinated, and able to see well.

Consult with your healthcare professional immediately if you have hallucinations, or symptoms of anaphylaxis such as rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this drug.

Consult with your healthcare professional before you decide to stop taking this drug. Your healthcare professional may slowly taper the amount you are taking before stopping completely to help prevent worsening of your condition and reduce the possibility of withdrawal symptoms.

This drug may cause dryness of the mouth and use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute for temporary relief.

Seek advice from your health care professional or dentist if your dry mouth continues for more than 2 weeks as this may increase the chance of dental disease, including tooth decay, gum disease, and fungal infections.

Side effects may vary for each individual and prompt medical attention should be given if they occur.  

Consult with your healthcare professional immediately if you experience symptoms of:

• chest pain or discomfort
• fever or chills
• nausea or vomiting
• nervousness pain or burning while urinating
• unusual tiredness
• blurred vision
• flu-like symptoms
• irregular heartbeat
• itching skin
• kidney stones
• right upper stomach tenderness
• seeing things that are not there
• shortness of breath
• weight gain
• continuing vomiting
• the general feeling of tiredness or weakness
• headache
• light-colored stools
• symptoms of overdose such as blurred vision
• change in consciousness
• chest pain or discomfort
• confusion
• decreased awareness or responsiveness
• difficult or troubled breathing
• dizziness
• faintness or lightheadedness when getting up from a lying position
• irregular, fast or slow, or shallow breathing
• lightheadedness, dizziness, or fainting
• loss of consciousness
• pale or blue lips, fingernails, or skin
• severe sleepiness
• sleepiness or unusual drowsiness
• slow or irregular heartbeat
• sweating
• unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. As your body adjusts to the medicine, the side effects will slowly disappear.

Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional.

Report any side effects to the FDA hotline at 1-800-FDA-1088.