Dacarbazine destroys cancer cells by adding an alkyl group. However, this medication also affects the normal cells of our body, which could lead to hair loss and other side effects.
Post-marketing experience has demonstrated the efficacy of dacarbazine in the treatment of islet cell carcinoma of the pancreas and soft tissue sarcomas.
This medication should be administered by a physician or at least under the supervision of one.
It is sold as a powder for either suspension or solution.
Dacarbazine can have serious effects on your body. That’s why you and your doctor need to discuss the risks and benefits carefully before deciding to use it in treatment.
You and your healthcare team need to determine if dacarbazine fits your situation. You do this by considering a number of factors.
Dacarbazine should not be given to patients who have had allergic reactions to it.
Tell your physician if you have had these types of reactions to dacarbazine or any of its components.
You should inform him/her if you have allergies to food, preservatives, animals, and/or other medications.
Dacarbazine’s effects have only been studied in adults and not in children. It also is not clear whether dacarbazine has the same effects in geriatric patient as it does in younger adults.
This medication has a pregnancy category of C, which means that not enough research has been done regarding its effects on pregnant women. Therefore, it should only be used if the benefits outweigh the risks. It hasn’t been determined whether dacarbazine can be passed through breast milk.
If you are a lactating woman, you and your doctor need to decide between stopping breast feeding and not using this medication.
Dacarbazine can also interact with other medicines, so you should give your physician a complete list of your current medications.
You should not receive live rotavirus vaccine while on dacarbazine treatment. Other vaccines that you should not get while taking this medication are as follows:
live adenovirus vaccine type 4,
adenovirus vaccine type 7,
Bacillus of Calmette and Guerin vaccineInfluenza Virus Vaccine,
You may also experience a burning or painful sensation when the injection is given. However, you should continue with therapy despite these effects. These usually go away after a few days.
Your healthcare provider can also teach you ways to decrease or manage these. The dosage and timing will depend on the condition being treated.
For malignant melanomas, the usual dose is 2 to 4.5 mg/kg daily for 10 days. Your doctor may repeat the treatment at an interval of 4 weeks.
For Hodgkin’s Disease, the dosage depends on your body surface. It’s usually 150 mg/square meter of body surface, daily for 5 days.
This can be repeated every 4 weeks as determined by your doctor.
4 Precautions to Take
You may not be hospitalized when getting your treatment but you need to make sure that you regularly check in with your doctor.
You also need to get all the necessary laboratory exams. This is to make sure that your condition is stable and that the medication is working.
As mentioned earlier, you should not get any vaccinations while getting therapy unless approved by your physician. You also need to avoid individuals who have recently received vaccinations.
Dacarbazine can lower your white blood cells and platelets. A decrease in white blood cells can compromise your immune system and make you prone to infection.
Exercise proper hygiene and avoid infected individuals. You can also use a protective face mask.
Consult your physician immediately if you have signs of infection like
You can be prone to excessive bleeding if your platelets are low. That’s why you need to be very careful when around sharp objects. You should also avoid activities that cause traumas or bruises. Brush your teeth and floss gently.
Tell your physician if you have any
unusual bruises,
bleeding,
tarry stools,
pinpoint spots on your skin.
Dacarbazine can also leak out of your vein and into your soft tissues.
Call your nurse or doctor if you notice pain, redness, or swelling at the injection site.
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