Before starting the treatment your doctor should be informed about conditions such as,
Allergy
Inform your doctor if you are allergic to any food, preservatives, dyes, or had an allergic reaction when you used this drug before.
Children
There are no adequate studies done which proves Trametinib harmful effects in children. Safety and efficacy have not been established.
Elderly
This medicine does not cause any different side effects or problem than it does in younger adults. However, elderly patient with liver, kidney and heart problems may require adjustment of dosage.
Pregnancy
It is a category D drug. It is not safe to use in pregnancy. It may cause harm to an unborn baby and can result in the loss of an unborn baby.
Breast Feeding
Trametinib is not known if it can pass into breast milk or not. Do not use this medication while nursing your child.
Drug Interactions
Trametinib may interact with other drugs. Your doctor should be informed of any other medicines which you are taking. He may want to change the dosage or drug.
Other Medical Conditions
Several other conditions may reduce its effectiveness.
Make sure you inform your doctor of conditions such as
Use it exactly as your doctor directed. Read the medication guide carefully. Ask your pharmacist if you have any queries.
Swallow the medicine whole. Do not crush, chew or break it. Do not take it if it is deformed. Take it at least 1 hour before or 2 hours after meal.
Dosage
It is different for different patients. Dosage mentioned below is an average dose. You must follow your doctor’s command.
For melanoma
Adults: 2 milligrams (mg) once a day.
Children
Use and dose must be determined by your doctor.
Missed dose
If you miss a dose, take it as soon as you remember it. If it almost a time for your next dose, skip the missed dose and continue your daily schedule. Doubling the dose is harmful.
Storage
Store it at room temperature.
Keep it away from children.
4 Precautions to Take
Your doctor should check your daily progress at regular visits. He may do a blood and urine test.
Use an effective form of birth control methods as Trametinib can harm an unborn baby.
It may cause difficulty in conceiving (to have children). Discuss with your doctor if you want children.
This medicine may increase your risk of heart failure if you have a history of heart disease.
Trametinib may increase the risk of developing other types of cancer, including another type of skin cancer, when used with dabrafenib. Discuss it with your doctor if you have any concern regarding it.
Fatal bleeding and blood clots in arms, legs or lungs have been reported if Trametinib is used along with Dabrafenib.
Inform you doctor immediately if you notice any
bleeding, including coughing up blood or blood clots,
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