Naglazyme

Naglazyme is used in injection form for the symptomatic management of an inherited disorder called mucopolysaccharidosis (MPS VI) or Maroteaux-Lamy syndrome.

These patients lack a certain enzyme in their bodies called N-acetylgalactosamine 4-sulfatase. This drug improves the walking and stair climbing ability in these patients.

This medicine can only be given only under the direct supervision of a doctor. This product is available in the solution dosage form.

Before using Naglazyme, you must know all about the risks and complications associated with it. So, the benefits of a drug should always be weighed against its associated risks.

Your doctor will consider these risks before prescribing the drug and will inform you about them.

Following factors should be considered before taking this drug:

Allergies: If you have had an allergic reaction to this drug in the past, inform your doctor. You should also tell your healthcare provider if you are allergic to any other drugs or food products.

Age-specific problems: The data regarding the effects of this medicine specific to the pediatric age group has not demonstrated any harmful effect specific tot his age group.

The studies specific to the geriatric age group have not been carried out yet.

Pregnancy: Regarding the safety of usage of this drug during pregnancy, it comes under “B” category, which means that clinical trials on animals have revealed no harmful effects to the developing fetus or relevant studies have not been performed in pregnant women.

Drug Interactions: Certain drugs should not be used together because they can interact inside the body which can have a harmful effect. On the other hand, certain drugs are allowed to be used together.

So, you should tell your doctor about any other medications you are taking. If there is a chance of interaction between those two drugs, the doctor may change the dose or may prescribe an alternative drug. 

Furthermore, certain medications should not be taken with alcohol or tobacco, which may also result in harmful interactions. Ask your doctor about the concurrent use of this drug along with alcohol or tobacco.

You should also inform your doctor about any other medical condition you may be suffering from, especially: 

• Lung diseases or breathing problems
• Sleep apnea (It may make this condition worse).
• Fluid volume overload
• Heart disease

Proper usage of Naglazyme requires strict adherence to your doctor’s orders. This medication should only be administered by a healthcare professional in a clinical setting. It is given through the intravenous route.

You may also be given an anti-allergic drug in order to prevent a severe allergic reaction from Naglazyme. It is usually given once a week. It should be given slowly over four hours.

Before using Naglazyme, there are some precautions you must take. Naglazyme has the tendency to cause fever, headache, skin reactions, and severe allergic reactions. Regular follow-up is necessary during and after the treatment.

It is important to allow your doctor to monitor your progress and to make sure that there aren’t any side effects from the medication. Contact your doctor if your symptoms have not improved even after taking the full course of treatment.

Tell your doctor right away if you have back pain, paralysis of the limbs, or loss of bladder or bowel control after receiving this medicine. These could be symptoms of a condition called spinal or cervical cord compression (SCC).

All the drugs have a tendency to cause unwanted effects along with its desired effects. Make sure you meet with your doctor in using Naglazyme to avoid unwanted potential side effects.

Although these side effects may occur only in a handful of patients but if they do occur, contact your physician immediately.

This medication is associated with following side effects:

• blurred or decreased vision
• dizziness
• chest pain
• difficult or labored breathing
• headache
• nervousness
• hernia of the naval
• pounding in the ears
• confusion
• slow or fast heartbeat
• bluish lips or skin
• swelling of the face
• tightness in the chest
• back pain
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• cough
• fever, chills, or sweating
• hives or welts
• loss of bladder control
• joint pain
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• loss of bowel control
• stomach pain
• nausea or vomiting
• paralysis of the limbs

Seek medical help instantly, if you experience any of these symptoms while on this medication. Also, contact your healthcare professional immediately, if have overdosed on this drug.

If any of these side effects becomes more bothersome or does not go away, contact your doctor.